… and implications of NLRP3 inflammasome activation in different cancer settings, and we
focus on the role of NLRP3 inflammasome in cancer in the present review. NLRP3 is a …

… role in numerous infectious diseases and some cancers. Therefore, fine tuning of NLRP3
inflammasome … mechanisms of NLRP3 inflammasome activation and its divergent roles in the …

… of the structure and function of NLRs and the related NBS-LRRs, a subset of plant resistance
(R) genes, with a particular focus on NLRs involved in inflammasome complex assembly. …

… also found a central role for mitochondrial dysfunction in NLRP3 inflammasome activation.
The … While it seems odd that two pathways with such divergent inflammatory outcomes would …

… divergent roles of inflammasome signalling in multiple tissues and organs, highlighting
its major functions in … is an upstream activator of NLRP3 inflammasome assembly. Non-canonical …

… Our results demonstrate the key role of IL-18 in inflammasome-driven disease, yet suggest
that other downstream mechanisms besides IL-18– and IL-1β–mediated inflammation are …

… in a variety of seemingly divergent diseases such as type II … receptor protein 3 (NLRP3)
inflammasome function in the host … compounds inhibit NLRP3 inflammasome function, the …

… ), which functions as a bridge connecting NLRP3 and … NLRP3 inflammasome and its
components or subcomplexes, with special focus on the inactive NLRP3 cage, the active NLRP3…

… function of NLRP proteins focused on their roles in apoptotic and inflammatory signaling
pathways via the formation of a large signaling platform (named inflammasome… such as NLRP3 (…

… Significance: Over the past 10 years, there has been a plethora of investigations centering
on the NLRP3 inflammasome and its role in fibrosis and other disease pathologies. To date, …