… cell membrane of nociceptive neurones as well as in membranes of intracellular calcium
stores like … While the associated channel conducts different ions, a major proportion is calcium. …

… Nociceptive neurones show a further important characteristic, … sensitivity that characterize
nociceptive neurones. There … calcium evoked by capsaicin raises the intracellular calcium …

… dorsal horn neurons result from activation of intracellular kinases by calcium entry through …
channels, that can alter the excitability of the neurons for tens of minutes after cessation of the …

… alterations in intracellular calcium homeostasis in primary and secondary nociceptive
neurons. … diabetes, the calcium signal is prolonged and calcium release from ryanodine-sensitive …

… , we hypothesized that this preference for a particular source of intracellular Ca 2+ may
represent a mechanism ensuring the selectivity and fidelity of signal transduction mediated by …

… TRPV1 is expressed in C-fiber nociceptive neurons and is required for the generation of heat
hyperalgesia [6]. Inflammatory heat hypersensitivity following bradykinin [33], NGF [33], TNF…

… The concentration of intracellular calcium is a key signal in primary nociceptive neurons. At
the peripheral terminals, it controls desensitization on repeated stimulation (Tominaga et al. …

… In the present study we set out to identify the intracellular signalling … ) neurones. A new
technique was developed to study rapid thermal sensitisation in large numbers of neurones by …

… conditions [Ca 2+ ] i is reduced, we conclude that this intracellular pathway mediating the
TRPV-1-induced I Ca(V) reduction is independent from [Ca 2+ ] i . While on the other side, […

… to interfere with calcium ion functions in neurons has been … by opioids and calcium antagonists
regarding nociceptive and … the level of intracellular Ca 2+ , such as Ca 2+ ionophores (…