… series of noncovalent inhibitors of cathepsin L have been designed to mimic the mode of
autoinhibition of procathepsin L. Just like the propeptide, these peptide-based inhibitors have a …

… amides based on dipeptidyl anilines for cathepsin K inhibition. These new non-covalent
inhibitors exhibit single digit nM inhibition of the cathepsin family. Molecular modeling studies on …

… against rabbit and human cysteine proteases cathepsins K, L… non-covalent inhibitors of
cathepsin K. Compounds 4b, 4e, and 4g exhibit high potency toward rabbit and human cathepsin …

… Here, we describe the first nonpeptidic and noncovalent inhibitor of cathepsin S that has high
… other cathepsins makes it an excellent tool for exploring the role of cathepsin S in humans. …

… = 20 nM) and selective noncovalent cathepsin S inhibitor 2 have recently … inhibitors with a
ketobenzimidazole piperidine resulted in a new series of potent, noncovalent CatS inhibitors. …

… —information that will be useful in the design of the noncovalent-type inhibitor. … spleen
cathepsin B–E64c complex. We would also like to propose a noncovalent-type inhibitor that can …

… derivative could be used as an effective cathepsin C inhibitor and encouraged us to …
To verify the cysteine cathepsin selectivity for our “non-peptidyl non-covalent Cat C inhibitors”, …

… Thus, the aim of this study was to investigate the noncovalent interactions of covalent
inhibitors. Using MD simulations, common structural features between different warhead types …

… , of late, noncovalent inhibitors. This review details advances in cathepsin S inhibitor design
as … on structure-activity relationships of the various covalent and noncovalent inhibitor series. …

… , most strategies to date have yielded covalent inhibitors. Here we present a series of non-covalent
β-amino-α-hydroxyalkanephosphonate dipeptidic inhibitors of cathepsin C, ranking …