… was to evaluate the potential of noncytotoxic doses of suramin to reverse chemotherapy
resistance in advanced chemonaive and chemoresistant non-small-cell lung cancer patients. …

… Our group has shown that non-cytotoxic dose of suramin (10-50 ?M) produces
chemosensitization in multiple preclinical tumor models, including chemo-pretreated tumors. …

… ) compared with patients who did not receive any prior suramin therapy (9.3 months). … of
non-cytotoxic suramin, a non-specific inhibitor of FGF signaling, as a chemosensitizer in patients …

… , non-cytotoxic suramin in combination with weekly paclitaxel was a well-tolerated combination
in patients with … have been awarded patents on the use of suramin as a chemosensitizer. …

… We reported that suramin is an effective chemosensitizer at noncytotoxic concentrations (<50 …
Suramin was tested in AIDS patients and later abandoned due to life-threatening toxicities. …

… Patients with advanced pancreatic cancer have a bleak … The present study evaluated
chemosensitization effect of suramin … In summary, non-cytotoxic suramin doses enhance the …

… Since our overall goal was to test suramin chemosensitization effect in pancreatic cancer, …
noncytotoxic suramin as a chemosensitizer in pancreatic cancer in current study. We …

… -fold enhancement of docetaxel activity by noncytotoxic concentrations of suramin. … patients.
We further showed in in vitro and in vivo studies that the chemosensitization effect of suramin …

… Different explanations are conceivable for the chemosensitizing effects of suramin on tumor
… use of suramin as a chemosensitizer in chemotherapy-naive lung cancer patients remain to …

… Suramin showed a biphasic effect on FU activity in RCC … Suramin did not significantly enhance
the activity of FU on … combination of IFN and suramin significantly enhanced the activity of …