… non-peptide antagonist binding to the rat receptor [25-271. In conclusion, several chimeric
approaches in the tachykinin … different non-peptide antagonists with their target receptor, a …

… non-peptide angiotensin receptor antagonists (DUP 753, L-158,809, EXP 3174) and the
non-peptide tachykinin NK2 receptor antagonist, … with the tachykinin NK3 receptor (1,9-l 1). We …

… determined the potency of the non-peptide antagonist, GR159897, at NK 2 receptors in
species which are representative of each of the subgroups of NK 2 receptors. Thus, we have …

… Three novel non-peptide tachykinin NK~ receptor antagonists were assessed on the
transient fall in mean arterial blood pressure and the salivation induced by iv substance P (0.65 …

… to create non-peptide small molecule agonists and antagonists of neuropeptide receptors
… The strategy has proven successful in the design of non-peptide small molecule antagonists …

… On the sciatic nerves of frogs, the tachykinin receptor antagonists inhibited action potentials
… to blocking tachykinin receptors, the non-peptide tachykinin receptor antagonists, CP-96,345…

… , highly potent non-peptide tachykinin NK 1 receptor antagonist, … evoked by the tachykinin
NK 1 receptor agonist, substance P … is a potent antagonist of NK 1 receptor-mediated cranial …

… non-peptide antagonist of tachykinin NK 1 receptors. … receptors from various animal species,
including humans. In vitro, it was a potent antagonist in functional assays for NK 1 receptors …

… non-peptide antagonist of tachykinin NK 2 receptors was evaluated in vitro in several bioassays
for the NK 2 receptor (… ) and compared to that of the peptide antagonists, MEN 10,376, L …

… experiments indicate that SB 223412, a novel, nonpeptide NK-3 receptor antagonist, has
the following features: (1) high affinity (K i = 1 nM vs. the hNK-3 receptor), (2) selectivity (∼140-…