Non-specific effects of vaccines: current evidence and potential implications

LCJ De Bree, VACM Koeken, LAB Joosten… - Seminars in …, 2018 - Elsevier
… or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-… -Guérin
(BCG), measles vaccine, and oral polio vaccine results in increased overall childhood …

Does oral polio vaccine have non-specific effects on all-cause mortality? Natural experiments within a randomised controlled trial of early measles vaccine

P Aaby, A Andersen, CL Martins, AB Fisker… - BMJ open, 2016 - bmjopen.bmj.com
vaccine (MV) may have beneficial non-specific effects (NSEs). If an unplanned intervention
with a vaccine (a natural experiment) modifies the estimated effect … oral polio vaccine (OPV). …

Beneficial nonspecific effects of oral polio vaccine (OPV): implications for the cessation of OPV?

P Aaby, CS Benn - Clinical Infectious Diseases, 2017 - academic.oup.com
nonspecific effects. One important implication of beneficial nonspecific effects of a vaccine is
… people of beneficial nonspecific effects by stopping the vaccine after the eradication of the …

Nonspecific effects of oral polio vaccine on diarrheal burden and etiology among Bangladeshi infants

A Upfill-Brown, M Taniuchi… - Clinical Infectious …, 2017 - academic.oup.com
… to nonspecificnonspecific effects of OPV versus inactivated polio vaccine (IPV) on total
and etiology-specific diarrheal incidence during the 3-month window following vaccination

Non-specific effects of vaccines: plausible and potentially important, but implications uncertain

AJ Pollard, A Finn, N Curtis - Archives of disease in childhood, 2017 - adc.bmj.com
Non-specific effects (NSE) or heterologous effects of vaccines are proposed to explain …
. The effect of Oral Polio Vaccine at birth on infant mortality: a randomized trial. Clin Infect …

The non-specific effects of vaccines

F Shann - Archives of disease in childhood, 2010 - adc.bmj.com
… -identical but closely related; non-specific or innate immunity refers … often say that a vaccine
has non-specific effects when it alters … in randomised trials to determine its effect on all-cause …

Non-specific effects of vaccines in developing countries: We need evidence about the effect of vaccines on mortality from all causes

F Shann - BMJ, 2000 - bmj.com
non-specific effects from measles, BCG, and DPT vaccines. … non-specific effects because
they stimulate Th1 immunity and that DPT vaccine may have adverse non-specific effects

Stopping Oral Polio Vaccine (OPV) after Defeating Poliomyelitis: A Pyrrhic Victory? Systematic Review of the Non-Specific Effects of OPV

P Aaby, S Nielsen, A Fisker, LM Pedersen… - … Non-Specific Effects …, 2021 - papers.ssrn.com
Non-specific effects of standard measles vaccine at 4.5 and 9 … Does oral polio vaccine
have non-specific effects on all-cause … measles vaccine. BMJ Open. 2016 Dec 23;6(12):e013335 …

Implications of vaccine non-specific effects on licensure of new vaccines

G Munkwase - Vaccine, 2024 - Elsevier
vaccine induced non-specific effects, mechanisms underlying trained immunity and known
vaccine non-specific effects… Bangladesh Nonspecific effects of oral polio vaccine on diarrheal …

Nonspecific effects of vaccines

D Goldblatt, E Miller - JAMA, 2014 - jamanetwork.com
… The possible implications of any such nonspecific vaccine effects for the infant immunization
schedule remain unclear. If such effects are documented with robust evidence, the infant …