… steroidal androgen receptor (AR) ligands limited their clinical use. Nonsteroidal AR ligands
… used and emerging nonsteroidal AR ligands, including antagonists, agonists, and selective …

… androgen receptor (AR) binding ability and in vitro functional activity of multiple series of
nonsteroidal … (SARs) of these nonsteroidal compounds. The AR binding properties of sixty-five …

… selective androgen receptor modulators, which structurally resemble the nonsteroidal AR …
hydroxyflutamide but act as agonists for the androgen receptor in a tissue-selective manner. …

… binding affinities (RBAs) for the rat androgen receptor (AR): up to 3 times that of testosterone
(T) and 100 times the RBAs of non-steroidal antiandrogens such as fiutamide, Casodex and …

… Structure of nonsteroidal androgen receptor ligands. Aromatic rings in R-bicalutamide
are designated A and B to clarify discussion of structural modifications in the text. …

We studied the three-dimensional quantitative structure−activity relationships (3D QSAR) of
70 structurally and functionally diverse androgen receptor (AR) binding compounds using …

… Molecular basis for secondary antiandrogen therapy in prostate cancer with mutant androgen
receptors (ARs) is not fully elucidated. MATERIALS AND METHODS. Effects of steroidal …

… non-steroidal androgens other than RU 58841 in clinical development. A number of companies,
including Bristol Myers Squibb, Ligand … of non-steroidal androgen receptor ligands that …

… more potent androgen receptor ligands, three-dimensional models for the human androgen
receptor ligand binding … Figure 1 Structures of androgen receptor ligands used in this study. …

… to the androgen receptor (AR), the mechanism by which ligands bind to the ligand binding
… to study the AR ligand binding mechanism of steroids and non-steroidal chemicals. The …