… different kinetic behavior of partly purified thymidine kinases from leukemic cells (59-62) …
thymidine kinase activity in malignant cells (44, 47, 65). Deficient regulation of thymidine kinase …

… thymidine kinase activity during the cell cycle, we have examined properties of the cytosolic
enzyme in cycling HeLa cells … from the mechanism that operates during the normal cell cycle. …

… The only significant difference from normal cells that we have observed so far is the loss of
cell cycledependent changes of steady state mRNA levels. In a recently published work ofour …

… to become multinucleated after cytochaliasin B treatment also suggests that one important
difference between malignant cells and most normal cells may be the ability of malignant …

… time cells begin mitosis rather than at the time DNA synthesis is complete. A study of the effect
of actinomycin D on thymidine kinase … of the cell cycle or late in the DNA synthesis period. …

… of different variants of thymidine kinase (TdR kinase), … replicative state of normal or transformed
cultured cells rather than the … of thymidine kinase found in actively growing cultured cells, …

… -dividing mammalian cells infected … cells thus facilitating the development of specific
antiviral therapeutics. Further, TK1 in leukemic cells may differ biochemically from normal cellular …

… normal cell division. There is a feed-back regulation of the action of thymidine kinase in the
cell: thymidine … further phosphorylation of thymidine, acts as an inhibitor to thymidine kinase. …

… that genes encoding thymidine kinase, dihydrofolate reductase, and both subunits of
nucleosidediphosphate reductase, which are well regulated on mRNA level in normal cells, lose …

… -phase of the cell cycle. In this review, the authors discuss serum levels of thymidine kinase
in a … In normal cells, TK activity is present only for a short period in the early S-phase, while its …