… cellular senescence. There is long-standing, albeit indirect, evidence that cellular senescence
… processes as diverse as normal growth control, differentiation, development, aging, and …

… senescence was the first cellular senescence subtype to be described [8]. It is induced after
serial propagation of normal … telomere erosion and the consequent increase in DNA lesions […

… Using HPV16E6 or mp53, for example, we have shown44 that although such cells escape
senescence, they subsequently undergo growth arrest after significantly fewer population …

… senescence-associated secretory phenotype (SASP) (Figure 1). Here, we review the molecular
mechanisms controlling cellular senescence … and characterizing senescent cells in vivo. …

… of cellular senescence to be … of senescence [8]. This indicates that at a certain point of
lineage differentiation, cells activate the senescence clock that ultimately induces cell senescence …

… SHAY, JW and WRIGHT, WE Quantitation of the frequency of immortalization of normal …
for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196, 33-39, …

… cellular processes. Here, we discuss the role of p53 in cellular senescence, a fundamental
cellular … proliferative lifespan, or replicative senescence, of normal human cells. Four decades …

… our view of cellular senescence as a trigger of tissue remodelling that acts during normal
embryonic development and upon tissue damage. To achieve this, senescent cells arrest their …

… that reconciles the normal and pathological roles for senescence. We discuss how a primary
role of cellular senescence is to contribute to normal development, cell plasticity and tissue …

… and modulators of cellular senescence establishment and induction of a senescence-associated
secretory phenotype, and provides an overview of cellular senescence as an emerging …