… .mental models lung injury and pulmonary fibrosis were used recent years (49 9 54). The
most … in the state of activation of cells in areas of active fibrosis, mature scar, and normal lung. …

… of abnormal and normal lung tissue visible side by side, without transition zones. There is
architectural destruction, dense fibrosis, and areas of relatively normal lung tissue (asterisk). …

… The clinical expression of idiopathic pulmonary fibrosis (IPF) is directly related to multiple
alterations in lung function… Lung fibrosis is defined by the replacement of the normal, compliant …

… matrix analysed by atomic force microscopy have revealed considerable matrix stiffening
in IPF lungs compared with normal lungs 86 . The influence of ECM stiffness on …

… This concept would suggest that the lung responds to injury in … reestablish normal lung
architecture with promotion of fibrosis; (… with idiopathic pulmonary fibrosis leads to destroyed lung …

… Fibroblastic foci (FF), often localized at the “leading edge” of normal and fibrotic lung, represent
a hallmark of the histopathology of UIP (1, 71). The presence and extent of FF in patients …

… and treatment options available for patients with idiopathic pulmonary fibrosis. This disease
has improved understanding of the mechanisms of lung fibrosis, and offers hope that similar …

… was the underlying cause of pulmonary fibrosis.1, 2 This … to the severity or outcome of
pulmonary fibrosis; and (2) that the … favors pathologic fibrosis instead of reestablishing normal lung …

… zones with associated honeycombing alternate with areas of relatively unaffected lung …
that are uniformly distributed within the interstitium of the lung. Areas of acute lung injury are not …

… The UIP pattern consists of normal lung alternating with patches of dense fibrosis, taking
the form of collagen sheets. The diagnosis of IPF requires correlation of the clinical setting with …