… Pneumonia is the second … , nosocomial pneumonia has been shown to possess an attributable
mortality rate as high as 30–50% ( 2, 4, 5 ). Patients developing nosocomial pneumonia, …

… avoided as monotherapy for nosocomial pneumonia. During the … One caveat to the nosocomial
pneumonia analyses was that … in the nosocomial bloodstream infection OPTAMA study, …

… Les fractions de réponse cumulative (FRC) furent calculées en utilisant les cibles
pharmacodynamiques pour chaque antibiotique et comparées avec les résultats de l'étude OPTAMA …

… The approach of the OPTAMA programme provides a novel tool which complements
susceptibility data to help in the selection of appropriate empirical antibiotic therapy. …

… The MYSTIC program contains a large set of data for nosocomial isolates from around
the world and associated information on the MICs for these isolates. This global, multicenter …

… OPTAMA programs in adults, n-13 As in the adult studies, the percent of susceptible isolates
from each of the institutions paralleled bactericidal activity for most agents. Many pediatric …

… However, none of these development programs have exemplified what we consider a
complete package by also considering pharmacodynamic thresholds at the site of infection (ie ELF…

… Using meropenem and cefotaxime MIC data from pediatric meningitis clinical trials, this
OPTAMA study used a Monte Carlo simulation to estimate pharmacodynamic exposures in the …

… Microbiology Antibiogram (OPTAMA) program aims at considering … Past OPTAMA studies
have evaluated the … -abdominal infections, and hospital-acquired pneumonia. In most situations…

… The incidence of nosocomial pneumonia is approximately 5 to 10 cases per 1000 hospital
admissions, represents approximately 25% of all infections in intensive care units (ICUs), and …