… Indeed, Nox4 expression is rapidly upregulated by the binding of agonists implicated in renal
diseases, such as transforming growth factor-β (TGF-β) [63], [73], angiotensin II (Ang II) [82]…

… In our study, 25 mmol/l d-glucose induced a significant increase in Nox4 expression with
associated increased generation of O 2 ·− and H 2 O 2 . These effects were not observed with …

… Here we show that Nox4 is the main source of renal ROS in a mouse model of diabetic
nephropathy induced by streptozotocin administration in ApoE −/− mice. Deletion of Nox4, but not …

… Nox4 have been widely evaluated in various types of kidney diseases including diabetic
nephropathy, hypertensive nephropathy… -induced Nox4 expression, which limits Nox4-mediated …

… Collectively, this study shows the deleterious effect of Nox4 expression in podocytes by …
experimental diabetes, emphasising the role of NOX4 as a target for new renoprotective agents. …

… cells, accompanied by the increases in NOX4 expression levels. In an in vitrostudy… NOX4
mRNA and protein levels. We then showed that miR-25 negatively regulated NOX4 expression …

… , we observed that Nox4 expression is restricted to the renal … that Nox4 is the main source of
ROS in diabetic nephropathy. … fibrosis by inducing Nox4 protein expression and subsequent …

… induced upregulation of extracellular matrix protein expression … of diabetic nephropathy
through pathways that include Nox4 … that Nox4 expression is upregulated in the diabetic kidney …

… Resveratrol treatment enhances AMPK activity and suppresses NOX4 expression in the
kidneys of diabetic mice. db/m or db/db mice were treated with or without resveratrol for 12 …

… At the time of the preparation of this paper, the role of Nox4 in diabetic kidney disease was
… The mechanism that drives upregulation of Nox4 expression in the diabetic mouse kidney …