… and induction of the Bcl-2 gene. Nrf2 mediated the up-regulation of Bcl-2, down-regulated …
Therefore, herein for the first time, we demonstrate that Nrf2-mediated up-regulation of Bcl-2 …

… 2 p45-related factor 2 (Nrf2) expression. Apoptosis was examined by measuring the ratio of
B-cell lymphoma 2 (Bcl-2)/Bcl-2-… The expression of HO-1 and nuclear translocation of Nrf2 …

… upregulation of Nrf2 in conjunction with an elevated transcriptional regulation of ABCG2,
Bcl-2 … Following silencing of the function of Nrf2 the cervical CSCs became more sensitive to …

… Next, we examined the effect of Nrf2-mediated upregulation of Bcl-xL protein on the
apoptosis marker proteins Bax and caspases. Hepa-1 cells treated with tBHQ or HEK293-…

… AS SKPs highly expressed Bcl-2 and Nrf2 after UVB exposure, it indicated that SKPs … might
be mediated by the upregulation of Bcl-2 and Nrf2 in our study. Bcl-2 and Nrf2, as two crucial …

… with Nrf2 and facilitates Nrf2 ubiquitination and degradation, resulting in the repression of …
The treatment of INrf2-overexpressing cells with etoposide upregulated Bax protein, induced …

… Our results revealed that upregulation of Nrf2 expression inhibited apoptosis in U251 … ratio
of Bcl2/Bax, decreased expression and activity of caspases 3, 9. And downregulation of Nrf2 …

… factor Nrf2, and a master regulator of cytoprotective gene expression. Although Nrf2 is a well
… In addition, anti-apoptotic Bcl-2/Bcl-xL protein was identified as another substrate for the …

… through examining the Keap1/Nrf2, NF-κB/P 38 MAPK and Bax/Bcl2/caspase-3 pathways. …
and NF-κB genes along with marked up-regulation of Nrf2 gene were observed. In addition, …

… Since ERK 1/2 is involved in radiation-induced NRF2 upregulation, we detected whether
inhibition of the autophagy process affects the phosphorylation of ERK 1/2. As shown in Fig. 6, …