… Discovery of SUN Proteins Our current understanding of the molecular mechanisms of
the SUN-KASH nuclear-envelope bridge is based on characterizations of genetic mutants in …

… Central to all of these processes is the assembly and function of conserved SUN–KASH
bridges… SUN and KASH proteins span the nuclear envelope. A trimer of SUN proteins (light blue, …

… Conserved residues at SUN-KASH interfaces function in LINC complex assembly and force
… at the nuclear envelope. Each panel shows a cartoon simulation focusing on the SUN-KASH …

… the hexameric SUN-KASH complex in which the SUN domain trimer binds three separate
KASH … the SUN domain may function as activation and inhibitory domains, respectively, for its …

… -84 (SUN) and Klarsicht/ANC-1/Syne-1 Homology (KASH) … at the NE, nuclear shape
determination, nuclear positioning, anti… current understanding of plant SUN, KASH, and other …

… nuclear membrane, recruitment of KASH proteins to the outer nuclear membrane requires
both KASH and SUN … blocks the targeting of KASH proteins to the outer nuclear membrane. In …

… Based on similarities between opisthokont KASH proteins and the only known plant KASH
proteins, WPP domain–interacting proteins, we used a computational method to identify the …

… Nuclear envelope bridges composed of inner nuclear membrane SUN proteins and outer
nuclear membrane KASH … rather than setting nuclear envelope spacing, SUN proteins have …

… disulfide bond during intracellular nuclear movement and positioning … SUN-KASH
interactions in two established experimental assays for intracellular nuclear positioning: nuclear …

… -84 (SUN) and Klarsicht/ANC-1/Syne-1 homology (KASH) domain–containing protein families
confer a range of previously unsuspected functional versatilities to the nuclear envelope (…