Nuclear localization of NCX: Role in Ca2+ handling and pathophysiological implications

A Secondo, T Petrozziello, V Tedeschi, F Boscia… - Cell Calcium, 2020 - Elsevier
… in handling Ca 2+ through the different nuclear compartments. Particularly, nuclear NCX
preferentially allows local Ca 2… Such transfer reduces abnormal elevation of [Ca 2+ ] n within the …

CaMKIIdelta subtypes: localization and function

CBB Gray, J Heller Brown - Frontiers in pharmacology, 2014 - frontiersin.org
nuclear localization when inserted into the variable domain of CaMKIIα and that mutagenesis
of the first two lysines in the insert abrogates the nuclear localization of … of Ca 2+ handling

Intracellular Ca2+ Handling

RJ Sayer - Molecular and Cellular Biology of Neuroprotection in …, 2002 - Springer
… the mechanisms involved in handling of Ca2+ within these … Some, such as the Golgi
apparatus98 and nuclear. envelope, … those key components ofthe Ca2+ handling system that may …

Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes

S Mishra, CBB Gray, S Miyamoto, DM Bers… - Circulation …, 2011 - Am Heart Assoc
… CaMKIIδ B and δ C subtypes differ by a nuclear localization … and presumed site of localized
Ca 2+ release determines … and PLN phosphorylation and Ca 2+ handling changes in the …

Nuclear localization of Cav2.2 and its distribution in the mouse central nervous system, and changes in the hippocampus during and after pilocarpine‐induced status …

JH Xu, L Long, J Wang, YC Tang, HT Hu… - Neuropathology and …, 2010 - Wiley Online Library
… The importance of calcium (Ca 2+ ) currents in seizure generation and in the establishment
of … In the handling and care of all animals, the guidelines for animal research of National …

Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling

AZ Wu, D Xu, N Yang, SF Lin, PS Chen, SE Cala… - Journal of molecular and …, 2016 - Elsevier
… role in affecting Ca 2 + handling, we used Fluo-4 based confocal Ca 2 + … Ca 2 + transients
not only in cytosol but also in nuclear regions. In saponin-permeabilized mouse CMs ([Ca 2

CaMKIIδ isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses

T Zhang, M Kohlhaas, J Backs, S Mishra… - Journal of Biological …, 2007 - ASBMB
Ca 2+ /calmodulin-dependent protein kinase II (CaMKII), which differ by the presence of a
nuclear localization … regulates cytosolic Ca 2+ handling and the δ B isoform, which localizes to …

Annexins and Ca2+ handling in the heart

E Camors, V Monceau… - Cardiovascular …, 2005 - academic.oup.com
… Recent findings underscoring the role of myocardial annexins as modulatory factors of Ca
2+ -handling proteins or even more as Ca 2+ -handling proteins will be summarized below. …

Cellular and subcellular localization of Na+–Ca2+ exchanger protein isoforms, NCX1, NCX2, and NCX3 in cerebral cortex and hippocampus of adult rat

A Minelli, P Castaldo, P Gobbi, S Salucci, S Magi… - Cell calcium, 2007 - Elsevier
handling Ca 2+ and Na + in both excitable and non-excitable cells. Perisynaptic localization
… role in neural cells, where variations of cytosolic Ca 2+ concentration, [Ca 2+ ] i , represent a …

Nuclear Ca2+ regulates cardiomyocyte function

S Guatimosim, MJ Amaya, MT Guerra, CJ Aguiar… - Cell calcium, 2008 - Elsevier
… functional consequences of buffering nuclear Ca 2+ in neonatal … to the nucleus with a nuclear
localization signal (Ad-PV-NLS) … of other proteins involved in Ca 2+ handling could be also …