… in the hMLH1 promoter region by PCRSSCP, we found a single-nucleotide polymorphism
at … By PCR-RFLP analysis with Pvu II for this polymorphism, we detected LOH in four tumors …

hMLH1 is a member of mismatch repair genes (MMR) that plays a crucial role in correcting
replication errors, cell cycle arrest, apoptosis and oxidative stress. We explored the risk …

… between two potentially functional polymorphisms within the hMLH1 promoter region and
overall … of the hMLH1 1151T/A polymorphism but not the hMLH1 − 93G/A polymorphism were …

… (B) The hMLH1 promoter was methylated homogeneously in the xenograft of the primary …
and unmethylated hMLH1. (C) The pattern of SNP at -93 nt of the hMLH1 promoter in 54 …

… We therefore evaluated the MLH1 −93 G>A polymorphism and associated clinical and tumor
characteristics in a sample of 1,211 individuals with colon cancer and 1,968 controls from …

… Single-nucleotide polymorphisms (SNPs) in the hMLH1 and hMSH2 can predispose
individuals to CRC with low to moderate penetrance, suggesting an important contribution of …

… Control sample 4 was informative for a single nucleotide polymorphism at base −72 and
was therefore used for analysis. The four panels (a–d) show methylated and unmethylated …

… More and more MMR genes are being found to contain common single nucleotide
polymorphisms (SNPs), which can predispose individuals to non-familial CRC with low to moderate …

… in hMLH1 or hMSH2. Our results confirm the importance of methylation of the hMLH1 promoter
… that methylation takes place in the absence of hMLH1 mutations in these tumors. Int. J. …

… in the MLH1 and MSH2 genes, numerous polymorphisms have also … Five single-nucleotide
polymorphisms (SNPs) are of … located in the MLH1 gene (ie, –93G>A promoter SNP, I219V …