Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: possible implications for opiate addiction
C Bond, KS LaForge, M Tian, D Melia… - Proceedings of the …, 1998 - National Acad Sciences
… To further identify SNPs in the mu opioid receptor and to characterize whether receptor …
polymorphism in the mu opioid receptor gene can affect the activity of the mu opioid receptor…
polymorphism in the mu opioid receptor gene can affect the activity of the mu opioid receptor…
The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor
T Kroslak, KS LaForge, RJ Gianotti, A Ho… - Journal of …, 2007 - Wiley Online Library
… In the first report of in vitro functional studies of receptors encoded by the … receptors encoded
by the 118G allele [mu opioid receptor (guanine substitution at coding sequence nucleotide …
by the 118G allele [mu opioid receptor (guanine substitution at coding sequence nucleotide …
A single nucleotide polymorphic mutation in the human μ-opioid receptor severely impairs receptor signaling
K Befort, D Filliol, FM Décaillot, C Gavériaux-Ruff… - Journal of Biological …, 2001 - ASBMB
… Opioid receptors also mediate the strong analgesic and addictive actions of opiate drugs. …
preferably act by activating the μ-opioid receptor (MOR) 1 rather than δ- or κ-opioid receptors ( …
preferably act by activating the μ-opioid receptor (MOR) 1 rather than δ- or κ-opioid receptors ( …
[HTML][HTML] The A118G single nucleotide polymorphism of the μ-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans
… associations between single nucleotide polymorphisms (SNP… an association of a δ-opioid
receptor gene (OPRD1) SNP … induced brain μ-opioid receptor binding during experimental …
receptor gene (OPRD1) SNP … induced brain μ-opioid receptor binding during experimental …
Opioid receptor and peptide gene polymorphisms: potential implications for addictions
KS LaForge, V Yuferov, MJ Kreek - European journal of pharmacology, 2000 - Elsevier
… nucleotide polymorphisms in exon I of the μ-opioid receptor … Polymorphisms in the human
κ-opioid receptor gene Four single nucleotide polymorphisms in the human κ-opioid receptor …
κ-opioid receptor gene Four single nucleotide polymorphisms in the human κ-opioid receptor …
Are μ-opioid receptor polymorphisms important for clinical opioid therapy?
J Lötsch, G Geisslinger - Trends in molecular medicine, 2005 - cell.com
… A common μ-opioid receptor polymorphism was associated … Another opioid receptor
mutation greatly impaired receptor … -nucleotide polymorphism in the human μ opioid receptor …
mutation greatly impaired receptor … -nucleotide polymorphism in the human μ opioid receptor …
[HTML][HTML] A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression
GM Miller, J Bendor, S Tiefenbacher, H Yang… - Molecular …, 2004 - nature.com
… We investigated the existence of variations in the nonhuman primate mu-opioid receptor …
the A118G single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene, a …
the A118G single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene, a …
Cellular signalling of non‐synonymous single‐nucleotide polymorphisms of the human μ‐opioid receptor (OPRM 1)
A Knapman, M Connor - British journal of pharmacology, 2015 - Wiley Online Library
… on the effects of μ-opioid receptor polymorphisms on receptor function, expression and …
Whether or not μ-opioid receptor SNPs contribute to individual variability in opioid responses …
Whether or not μ-opioid receptor SNPs contribute to individual variability in opioid responses …
A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability
P Huang, C Chen, SD Mague, JA Blendy… - Biochemical …, 2012 - portlandpress.com
… The A118G SNP (single nucleotide polymorphism) of the hMOPR [human MOPR (μ opioid
receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous …
receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous …
A118G single nucleotide polymorphism of human μ-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after …
AT Sia, Y Lim, ECP Lim, RWC Goh, HY Law… - The Journal of the …, 2008 - pubs.asahq.org
… In conclusion, our study showed that the A118G polymorphism of the human μ-opioid receptor
has a significant effect on pain perception, analgesic requirement, and nausea for the first …
has a significant effect on pain perception, analgesic requirement, and nausea for the first …
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