… to this cystine transporter as SLC7A11 … nutrient dependency in cancer cells. Finally, we will
discuss how our understanding of SLC7A11 function in ferroptosis and nutrient dependency …

… In summary, system x − c is a cystine/glutamate antiporter consisting of the transporter
subunit SLC7A11 and regulatory subunit SLC3A2. System x − c -mediated transport of …

… as cystine) may cause co-dependency of another nutrient (… we can utilize in nutrient
transporter inhibition-mediated tumor … to be capable of suppressing cystine uptake promoted by …

… highly dependent on specific nutrients for survival 1,2,3 . Limiting the supply of such nutrients
… Our understanding of nutrient dependency in cancer cells can provide insights for targeting …

… may be highly dependent on certain nutrients for survival, which … The glutamate/cystine
antiporter solute carrier family 7 … enhances cancer cell dependence on glucose and renders …

… show limited nutritional flexibility and are highly dependent on … transporter that exports
glutamate in exchange for cystine. … ), because cystine is the oxidized dimer of cysteine, a critical …

… how the cystine transporter, xCT, and exogenous cystine fuel … of key nutrients such as glucose
or cysteine upregulates the … a methionine dependency rather than a cystine dependency. …

… Met4p-dependent sulfur regulatory network. The results reveal that YLL055w encodes the …
cysteine transporter in S. cerevisiae, which we have named YCT1 (yeast cysteine transporter). …

… However, we found that dietary supplementation with l-cysteine showed a dosage-dependent
inhibitory effect … Thus, dysfunction of l-glutamate transporters is commonly associated with …

… To keep consistency, in our following discussion we will refer to this cystine transporter …
cells, are largely dependent on taking up extracellular cystine to maintain redox homeostasis and …