Diminished adrenal sensitivity and ACTH efficacy in obese premenopausal women

F Roelfsema, H Pijl, DM Keenan… - European journal of …, 2012 - academic.oup.com
… In this study we demonstrate that the ACTH–cortisol concentration–effect … obese
premenopausal women compared with normal-weight women and characterized by decreased …

Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment

P Kok, SW Kok, MM Buijs… - American Journal …, 2004 - journals.physiology.org
… In conclusion, spontaneous ACTH secretion is enhanced in obese premenopausal women,
… FFA concentrations by acipimox blunts ACTH release in obese women, which suggests that …

Disordered and increased adrenocorticotropin secretion with diminished adrenocorticotropin potency in obese in premenopausal women

F Roelfsema, P Kok, M Frolich… - The Journal of Clinical …, 2009 - academic.oup.com
… It is important to emphasize that our analysis estimated the physiological potency of
endogenous ACTH but did not address maximal efficacy as obtained with pharmacological doses. …

Effects of menopause on hepatic 11β-hydroxysteroid dehydrogenase type 1 activity and adrenal sensitivity to adrenocorticotropin in healthy non-obese women

S Li, W Liu, L Wang, R Huang, Q Chen… - Gynecological …, 2011 - Taylor & Francis
… did not effect the negative feedback effectiveness at pituitary level. But we found that liver …
to ACTH increased in the postmenopausal women compared with the premenopausal women. …

Gonadotropin-releasing hormone agonist in premenopausal women does not alter hypothalamic-pituitary-adrenal axis response to corticotropin-releasing hormone

KM Gavin, KL Shea, E Gibbons… - American Journal …, 2018 - journals.physiology.org
… abdominal fat accrual (43). Accordingly, elevated HPA axis activity in postmenopausal women
… Our hypothesis was that the HPA axis response to corticotropin-releasing hormone (CRH) …

[HTML][HTML] Obesity and androgens: facts and perspectives

R Pasquali - Fertility and sterility, 2006 - Elsevier
obese and normal-weight men had higher basal ACTH and cortisol levels than their female
counterparts, and that obese women … -weight or obese premenopausal women with normal …

Obesity and androgens in women

R Pasquali, C Oriolo - Hyperandrogenism in Women, 2019 - karger.com
… corticotropinreleasing hormone release and ACTH secre tion [… efficacy of bariatric surgery in
severely obese PCOS women. … and oncological diseases in obese postmenopausal women. …

Endocrine changes in obesity

S Sidhu, T Parikh, KD Burman - 2015 - europepmc.org
obese premenopausal women; suggesting decreased responsiveness of the adrenal
gland to the ACTH … , that premenopausal women exhibit diminished ACTH efficacy (maximal …

The cortisol and ACTH response to Dex/CRH testing in women with and without perimenopausal depression

GM Guerrieri, R Ben Dor, X Li, SM Wei… - The Journal of …, 2021 - academic.oup.com
… Nondepressed perimenopausal women between ages 40 and 60 years were recruited to
participate as a control group in this study. These control women participated in a screening …

Increased circadian prolactin release is blunted after body weight loss in obese premenopausal women

P Kok, F Roelfsema, JG Langendonk… - American Journal …, 2006 - journals.physiology.org
… Therefore, we hypothesized that enhanced PRL release in obese … 11 obese premenopausal
women (BMI 33.3 ± 0.7 kg/m 2 ) before and after weight loss (50% reduction of overweight/…