… insulin would affect insulin sensitivity or lifespan in male mice. Therefore, we used female
mice as … insulin levels might modulate age-dependent insulin resistance and extend lifespan. …

… To confirm these results, we characterized a second group of young (6-month-old) and
aged (25-month-old) mice with similar body composition (Supporting Information Figure S1A). …

… cells per islet is high, and the insulin content in the islet is high in these old animals.Several
studies using animal models for type 2 diabetes, such as the GK rat17 and the Akita …

… insulin sensitivity, which we report here, may be explained by our use of a much more sensitive
test to evaluate insulin sensitivity: … insulin sensitivity in old antibody-treated mice, the less …

… mice displayed similar insulin sensitivity and similar insulinaemia compared with Cb2 +/+
mice … the results in high fat fed mice, insulin sensitivity was enhanced in 12-month-old Cb2 −/− …

… In our study, we show that chronic rapamycin treatment of young as well as old mice causes
glucose intolerance in a dose-dependent and reversible manner (Fig. 2). Under standard …

… tolerance test was performed by giving 0.75 units/kg of body weight of insulin to 2-month-old
mice (Left). Values are expressed as the % of the glucose levels at 0 min point and …

… -week-old mice were injected intraperitoneally with 45 pmol/g human regular insulin. The
liver and gastrocnemius muscle were removed 3 and 5 min after insulin injection, respectively, …

… in quantifying insulin sensitivity of the brain … insulin sensitivity is closely correlated with
obesity and hyperlipidaemia. Meanwhile, animal models of obesity (eg the db/db and ob/ob mouse…

… Although insulin sensitivity was not altered in the old mice, … of the OLD mice can properly
handle a small amount of insulin … stimulates insulin secretion, the liver of the OLD mice cannot …