Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan
… insulin would affect insulin sensitivity or lifespan in male mice. Therefore, we used female
mice as … insulin levels might modulate age-dependent insulin resistance and extend lifespan. …
mice as … insulin levels might modulate age-dependent insulin resistance and extend lifespan. …
Adiposity‐independent effects of aging on insulin sensitivity and clearance in mice and humans
N Ehrhardt, J Cui, S Dagdeviren, S Saengnipanthkul… - …, 2019 - Wiley Online Library
… To confirm these results, we characterized a second group of young (6-month-old) and
aged (25-month-old) mice with similar body composition (Supporting Information Figure S1A). …
aged (25-month-old) mice with similar body composition (Supporting Information Figure S1A). …
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging
T Utsugi, T Ohno, Y Ohyama, T Uchiyama, Y Saito… - Metabolism, 2000 - Elsevier
… cells per islet is high, and the insulin content in the islet is high in these old animals.Several
studies using animal models for type 2 diabetes, such as the GK rat17 and the Akita …
studies using animal models for type 2 diabetes, such as the GK rat17 and the Akita …
Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice
JPG Camporez, MC Petersen… - Proceedings of the …, 2016 - National Acad Sciences
… insulin sensitivity, which we report here, may be explained by our use of a much more sensitive
test to evaluate insulin sensitivity: … insulin sensitivity in old antibody-treated mice, the less …
test to evaluate insulin sensitivity: … insulin sensitivity in old antibody-treated mice, the less …
Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age
J Agudo, M Martin, C Roca, M Molas, AS Bura… - Diabetologia, 2010 - Springer
… mice displayed similar insulin sensitivity and similar insulinaemia compared with Cb2 +/+
mice … the results in high fat fed mice, insulin sensitivity was enhanced in 12-month-old Cb2 −/− …
mice … the results in high fat fed mice, insulin sensitivity was enhanced in 12-month-old Cb2 −/− …
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
… In our study, we show that chronic rapamycin treatment of young as well as old mice causes
glucose intolerance in a dose-dependent and reversible manner (Fig. 2). Under standard …
glucose intolerance in a dose-dependent and reversible manner (Fig. 2). Under standard …
Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase
K Ueki, CM Yballe, SM Brachmann… - Proceedings of the …, 2002 - National Acad Sciences
… tolerance test was performed by giving 0.75 units/kg of body weight of insulin to 2-month-old
mice (Left). Values are expressed as the % of the glucose levels at 0 min point and …
mice (Left). Values are expressed as the % of the glucose levels at 0 min point and …
Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.
Y Ogawa, H Masuzaki, K Hosoda, M Aizawa-Abe… - Diabetes, 1999 - Am Diabetes Assoc
… -week-old mice were injected intraperitoneally with 45 pmol/g human regular insulin. The
liver and gastrocnemius muscle were removed 3 and 5 min after insulin injection, respectively, …
liver and gastrocnemius muscle were removed 3 and 5 min after insulin injection, respectively, …
Insulin resistance in the brain: an old-age or new-age problem?
R Williamson, A McNeilly, C Sutherland - Biochemical pharmacology, 2012 - Elsevier
… in quantifying insulin sensitivity of the brain … insulin sensitivity is closely correlated with
obesity and hyperlipidaemia. Meanwhile, animal models of obesity (eg the db/db and ob/ob mouse…
obesity and hyperlipidaemia. Meanwhile, animal models of obesity (eg the db/db and ob/ob mouse…
Aging reduces insulin clearance in mice
… Although insulin sensitivity was not altered in the old mice, … of the OLD mice can properly
handle a small amount of insulin … stimulates insulin secretion, the liver of the OLD mice cannot …
handle a small amount of insulin … stimulates insulin secretion, the liver of the OLD mice cannot …
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