DNA methylation as a therapeutic target in hematologic disorders: recent results in older patients with myelodysplasia and acute myeloid leukemia

B Rüter, PW Wijermans, M Lübbert - International journal of hematology, 2004 - Springer
… inhibit DNA methylation have been developed to specifically target this hypermethylation
more than 25 years ago, when their methylation-inhibitory activities, even at low concentrations…

Global DNA methylation in old subjects is correlated with frailty

D Bellizzi, P D'Aquila, A Montesanto, A Corsonello… - Age, 2012 - Springer
… global DNA methylation levels and frailty. We found that the global DNA methylation levels
… to a significant decrease in the global DNA methylation levels. These results suggest that …

DNA methylation pattern of gene promoters of major neurotransmitter systems in older patients with schizophrenia with severe and mild cognitive impairment

R Alelú‐Paz, A González‐Corpas… - … journal of geriatric …, 2015 - Wiley Online Library
DNA methylation patterns in multiple gene promoters in several brain structures from older
patients … an analysis in the normal and schizophrenic older human brain. Our results indicate …

Age-associated decrease in global DNA methylation in patients with major depression

PT Tseng, PY Lin, Y Lee, CF Hung… - Neuropsychiatric …, 2014 - Taylor & Francis
… In summary, although we found a decrease in global DNA methylation in older patients with
depression compared to healthy controls, this can possibly be explained by the fact that the …

The role of DNA methylation in aging, rejuvenation, and age-related disease

AA Johnson, K Akman, SRG Calimport… - Rejuvenation …, 2012 - liebertpub.com
… Aging is strongly correlated with changes in DNA methylation. DNA methylation and …
Global DNA methylation in old subjects is correlated with frailty. Age (Dordr) 2012;34:169–…

Age-related DNA methylation changes in normal human prostate tissues

B Kwabi-Addo, W Chung, L Shen, M Ittmann… - Clinical cancer …, 2007 - AACR
… age-related manner, suggesting that the use of GSTP1 as a diagnostic tool must be carried
out with caution especially when using it as a tool for analyzing samples from older patients. …

[HTML][HTML] Role of age-related changes in DNA methylation in the disproportionate susceptibility and worse outcomes of sepsis in older adults

X Lang, L Shen, T Zhu, W Zhao, Y Chen, C Zhu… - Frontiers in …, 2022 - frontiersin.org
… Our results demonstrated the existence of DNA methylation changes in sepsis patients vs.
controls, supporting that epigenetic alterations may play an important role in the pathogenesis …

DNA methylation and cognitive functioning in healthy older adults

OJG Schiepers, MPJ Van Boxtel… - British journal of …, 2012 - cambridge.org
… T genotype, we found that global DNA methylation was not related to … DNA methylation,
as measured in leucocytes, might be associated with cognitive functioning in healthy older

Association between early promoter-specific DNA methylation changes and outcome in older acute myeloid leukemia patients

NJ Achille, M Othus, K Phelan, S Zhang, K Cooper… - Leukemia research, 2016 - Elsevier
… Here we report DNA methylation and gene expression analyses in peripheral blood samples
from a phase 2 trial of older patients with AML treated with azacitine and GO therapy. We …

[HTML][HTML] Accelerated DNA methylation age and the use of antihypertensive medication among older adults

X Gao, E Colicino, J Shen, AC Just… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
patients with hypertension [18,19], and may also be associated with a decreased risk of
cognitive decline and incident dementia [20]. As DNA methylation … cohort of older veterans living …