… To assess whether the increased expression of the extrinsic apoptotic pathway in OPCs
could result in enhanced susceptibility to TNF-α–mediated injury, we exposed cultures, …

… susceptibility to gray and white matter injury at E22 was related to the timing of appearance
of late oligodendrocyte progenitors (… During normal rabbit oligodendrocyte (OL) lineage …

… in susceptibility to HI across the OL lineage. We demonstrate enhanced susceptibility of late
OL progenitors … Late OL progenitors had two major responses to HI: death that is associated …

… Several studies have shown that the progression of oligodendrocyte progenitors along the
lineage correlates with increased susceptibility to death stimuli. The molecular basis of this …

… are markedly more susceptible than mature OLs to free radical-mediated injury (Back et al.,
1998; Fern and Moller, 2000). However, the susceptibility of human OL progenitors to hypoxia…

… molecules might modulate cell susceptibility or healing events. The remyelination that
follows brain lesions is dependent on the recruitment of oligodendrocyte progenitor cells (OPCs) …

… Oligodendrocyte progenitor cells (OPCs) are a proliferative … differentiation and mature
oligodendrocyte numbers occurred … , importantly, highlights the sensitivity of OPCs to fractionated …

… for ATP synthesis, while oligodendrocytes isolated from the adult rat brain preferentially use
glycolysis, 43 which suggests increased susceptibility of immature cells to oxidative damage…

… oligodendrocytes. In the last two decades, a fourth class of glia has emerged, called
oligodendrocyte progenitor … population of progenitors that give rise to oligodendrocytes during …

… identified no differences in the levels of TNFR1, TNFR2, and CXCR3 expression (3),
suggesting that the increased susceptibility of OPCs to inflammatory/apoptotic stimuli may not be …