… The bone-cartilage interface is an important … cartilage and subchondral bone are not well
understood. This review focuses on the regulatory processes at the cartilage-subchondral bone …

… Hence, factors involved in the control of bone homoeostasis, such as OPG and RANKL, …
at the implication of OPG, RANK and RANKL in human OA cartilage metabolism and, more …

… of RANKL and OPG in bone is a major determinant of bone … role of the RANKL/RANK/OPG
system in bone modeling and … bone matrix on the surfaces of these islands of cartilage to …

… Changes in subchondral bone morphology have been … in cartilage RANKL and OPG
expression by chondrocytes demonstrated in this study is consistent with cartilage regulating bone …

… resorbing effects and thus preventing the destruction of the articular bone and cartilage
without influencing the evolution of the inflammatory process. All these mechanisms justify the …

… This article reviews the roles of the RANKL/RANK/OPG system in bone and other tissues. …
(Other durable structures, such as tendons, teeth, and cartilage, are not remodeled.) The main …

… Osteoarthritis (OA) is the most common joint pathology and recent studies suggest that, in
this disease, the subchondral bone is intimately involved in cartilage degradation and loss. In …

… κB ligand (RANKL)/osteoprotegerin (OPG) system. This review summarizes the RANKL/OPG
system … of the cartilaginous growth plates of endochondral bone. Osteopetrosis observed in …

… decoy receptor for RANKL, prevents RANKL from binding to RANK and bone resorption1-6. …
with OA celecoxib decreased RANKL synthesis in the cartilage by increasing the OPG:…

… ratio, reflecting bone destruction, which is … of RANKL:OPG in the development of bone
destruction and erosion in RA. In this context, it would be of great interest to study whether RANKL …