The biology of the opioid growth factor receptor (OGFr)

IS Zagon, MF Verderame, PJ McLaughlin - Brain Research Reviews, 2002 - Elsevier
opioid receptors do not influence in vivo or in vitro growth, we reached the conclusion that this
was an opioid receptor … warranted distinction from other opioid receptors. Hence, since this …

The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer

FE Lennon, T Mirzapoiazova, B Mambetsariev… - PloS one, 2014 - journals.plos.org
… tumor growth and metastasis, this study examined whether MOR regulates growth factor
receptor … Our results indicate MOR regulates opioid and growth factor-induced EGF receptor

μ-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation

MM Belcheva, M Szùcs, D Wang, W Sadee… - Journal of Biological …, 2001 - ASBMB
… entails growth factor receptor … μ-opioid receptor (MOR) expressed in HEK293 cells and
involves calmodulin (CaM). Stimulation of MOR resulted in both epidermal growth factor receptor (…

The fibroblast growth factor receptor is at the site of convergence between μ-opioid receptor and growth factor signaling pathways in rat C6 glioma cells

MM Belcheva, PD Haas, Y Tan, VM Heaton… - Journal of Pharmacology …, 2002 - ASPET
… Although the μ-opioid receptor (MOR) mediates stimulation of ERK via EGFR … fibroblast
growth factor (FGF) receptor (FGFR) transactivation in the convergence of MOR and growth factor

Nerve growth factor-regulated emergence of functional δ-opioid receptors

B Bie, Z Zhang, YQ Cai, W Zhu, Y Zhang… - Journal of …, 2010 - Soc Neuroscience
… In this study, we demonstrate that δ-opioid receptor (DOPr), a GPCR constitutively targeted
… and becomes functional by the neurotrophin nerve growth factor (NGF) in native brainstem …

[HTML][HTML] Opioid growth factor modulates angiogenesis

J Blebea, JE Mazo, TK Kihara, JH Vu… - Journal of vascular …, 2000 - Elsevier
… of opioid growth factor's effects were comparable to those seen with retinoic acid, whereas
inhibition of opioid growth factor … is receptor mediated because naloxone, the opioid receptor

Role of GPCR (mu-opioid)–receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II)

D Araldi, LF Ferrari, JD Levine - Pain, 2018 - journals.lww.com
… , which has 2 components: opioid-induced hyperalgesia (OIH) and … Because the epidermal
growth factor receptor (EGFR) … II hyperalgesic priming (opioid-induced hyperalgesia and …

Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy

R Wang, Y Zhang, F Shan - International Immunopharmacology, 2019 - Elsevier
… This receptor was originally named zeta, to follow the naming principle of opioid receptors. …
nature of the zeta receptor differs from the three classical opioid receptors (mu, delta, and …

… δ-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor …

DA Eisinger, H Ammer - Molecular Pharmacology, 2011 - ASPET
… of MMPs to cleave a broad spectrum of growth factor precursors, the present study raises
the intriguing possibility that opioid receptors might serve as potential drug targets to interfere …

Conserved expression of the opioid growth factor,[Met5] enkephalin, and the zeta (ζ) opioid receptor in vertebrate cornea

IS Zagon, JW Sassani, G Allison, PJ McLaughlin - Brain research, 1995 - Elsevier
… an enkephalin growth factor and its opioid receptor now reveals the … Thus, the discovery
that both the OGF and the £" opioid receptoropioid system. The presence of both OGF and its …