… In conclusion, our study extends our observations that opioids and the opioid receptor
affect tumour progression in humans and suggests a potential use of MOR antagonists as a …

… exogenous opioids, supporting an underlying role of the MOR in lung cancer progression.
Taken together, our data suggest a possible direct effect of opioids on lung cancer progression…

… opioid receptor (MOR) can influence cancer progression. Based on our previous observations
that overexpression of MOR in human non-small cell lung cancer … factor receptor signaling …

… raised the possibility that μ-opioid agonists can influence cancer progression. Based on our
… μ-opioid receptor (MOR) is up-regulated in several types of non-small cell lung cancer, this …

… Opioids exert their effects by interacting with the pu, 8, and K opioid receptor types (for … ),
we found that the lung cancer cell lines exhibited multiple opioid receptor types (Table 2). The …

… the lung cancer receptor to be similar, if not identical, to the human brain ñopioid receptor.
The lack of high-affinity [3H](+ 1BW373U86 binding in normal mouse lung membranes …

… κ-opioid receptors in either NHLF, HCC827 or H1975 cells. (A) Upper: Representative RT-PCR
for mRNAs of κ-opioid receptors … The values for κ-opioid receptor mRNA were normalised …

… First, the expression of opioid receptors may differ according to cancer cell type. Lung
cancer cell lines tested in this study did not express MOR significantly but markedly expressed …

… described within human lung cancer tissue. We … opioid receptor DOR in cancerous cells
of lung tissue. Moreover, we were able to identify opioid receptors such as DOR in lung cancer …

… The abundance of opioid receptors on lung cancer cells presents an opportunity for both
diagnosis and treatment. After activation, MOR may undergo endocytosis and recycling which …