Individualization of drug therapy: history, present state, and opportunities for the future

LJ Lesko, S Schmidt - Clinical pharmacology & Therapeutics, 2012 - Wiley Online Library
Individualization of drug therapy, described as tailoring drug selection and drug dosing to a
given patient, has been an objective of physicians and other health‐care providers for …

New drug targets for genomic cancer therapy successes, limitations, opportunities and future challenges

P Workman - Current Cancer Drug Targets, 2001 - ingentaconnect.com
drug therapy is undergoing a major transition from the previous pregenomic cytotoxic era to
the new postgenomic era. Future mechanism-based therapeutic … to show greater therapeutic

Future opportunities for drug therapy in peptic ulcer disease

A Garner - Scandinavian Journal of Gastroenterology, 1986 - Taylor & Francis
… and high level of investment in drug therapy for peptic ulcer and associated disorders, …
therapeutic area (worth f2.3 billion in 1985). This article considers opportunities for drug therapy in …

Drug discovery in ophthalmology: past success, present challenges, and future opportunities

NJD Gower, RJ Barry, MR Edmunds, LC Titcomb… - BMC …, 2016 - Springer
… and consider what ophthalmic drug discovery can learn from … to the future, we argue that
investment in ophthalmic drugfuture holds great promise for safe and effective therapies for …

Opportunities for improving therapy development in ALS

L Bruijn, M Cudkowicz… - … Lateral Sclerosis and …, 2014 - Taylor & Francis
… We recommend that future phase II clinical trials in ALS proceed when the proposed
treatment is directed at targets that are likely to be involved in ALS pathogenesis in a defined …

Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges

G Fuhrmann, IK Herrmann, MM Stevens - Nano today, 2015 - Elsevier
drug targeting efficiencies. Recent developments in the field have aimed at studying EVs as
novel drug … In this review, we discuss new research avenues in diagnostics and drug therapy

Pharmacodynamic therapeutic drug monitoring for cancer: challenges, advances, and future opportunities

GJ Veal, EB Amankwatia, MN Paludetto… - Therapeutic Drug …, 2019 - journals.lww.com
… responses to therapy, and drug resistance. These factors may prove vital in determining an
optimum therapeutic dose during PD monitoring of existing and future targeted therapies. At …

Challenges and opportunities in the application of pharmacogenetics to antiepileptic drug therapy

TN Ferraro, DJ Dlugos, RJ Buono - Pharmacogenomics, 2006 - Taylor & Francis
drug (AED) therapy. Initial studies have focused on genes whose products play a putatively
important role in AED pharmacology, particularly drug transporter proteins, drug … of future

Current limitations and future opportunities for epigenetic therapies

F Cherblanc, N Chapman-Rothe, R Brown… - Future medicinal …, 2012 - Taylor & Francis
… This article reviews progress in epigenetic therapies that hope to improve the treatment of
therapy, maintenance of a pharmacodynamic response and achievement of a therapeutic

Challenges and opportunities for drug discovery in psychiatric disorders: the drug hunters' perspective

EHF Wong, F Yocca, MA Smith… - International Journal of …, 2010 - academic.oup.com
… We believe that for novel targets and novel therapeutic approaches, it will be more efficient
… This review has outlined former practices, current challenges and future opportunities in …