Dissolution testing as a prognostic tool for oral drug absorption: dissolution behavior of glibenclamide

R Löbenberg, J Krämer, VP Shah, GL Amidon… - Pharmaceutical …, 2000 - Springer
… some cases we also tested the dissolution behavior in fed state simulating intestinal fluid (FeSSIF),
to gain a better understand- Dissolution tests are a standard method used to ensure …

Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility

C Taniguchi, Y Kawabata, K Wada… - Expert opinion on …, 2014 - Taylor & Francis
… be effective approaches to improve drug dissolution and oral absorption. In both approaches,
… pH-independent dissolution behavior, resulting in improved oral absorption. Salt formation …

Improving dissolution behavior and oral absorption of drugs with pH-dependent solubility using ph modifiers: a physiologically realistic mass transport analysis

N Salehi, G Kuminek, J Al-Gousous… - Molecular …, 2021 - ACS Publications
… ’ dissolution rate and extent under high-gastric pH dissolution conditions, since the oral
absorption of BCS class II drugs can be limited by either the solubility or the dissolution rate …

Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant media

ES Kostewicz, U Brauns, R Becker… - Pharmaceutical …, 2002 - search.proquest.com
… In the present study the aim was to assess the potential of in vitro solubility and dissolution
studies using physiological relevant GI media to predict the in vivo absorption behavior of the …

Dissolution behaviors and gastrointestinal absorption of phenytoin in phenytoin-polyvinylpyrrolidone coprecipitate

H Sekikawa, J FUJIWARA, T NAGANUMA… - Chemical and …, 1978 - jstage.jst.go.jp
… of the metabolite excreted following the oral administration of the … almost completely absorbed
following oral administration of … Dissolution Studies The dissolution behaviors of phenytoin …

… evaluation of supersaturation/precipitation/re-dissolution behavior of cinnarizine, a lipophilic weak base, in the gastrointestinal tract: the key process of oral absorption

Y Tanaka, A Kawakami, A Nanimatsu, M Horio… - European Journal of …, 2017 - Elsevier
… In this study, the in vivo absorption behavior of CNZ after oral administration as a solution
at different concentrations was evaluated. Although different supersaturation stabilities were …

Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug

Y Fujioka, Y Metsugi, K Ogawara, K Higaki… - International journal of …, 2008 - Elsevier
… Particularly, focusing on the segment-dependent absorbability of drugs and GI transit, we
have reported the successful analysis and prediction of oral absorption behaviors of drugs, …

In vitro studies on the dissolution and absorption behaviour of orally administered drugs, and the connection to their bioavailability

H STRICKER - The quality control of medicines, 1976 - Elsevier
… in vitro studies on the dissolution and absorption behavior of orally administered drugs,
and the connection to their bioavailability. In vitro studies of drug dissolution for stability and …

Novel nano-crystalline solid dispersion of nobiletin with improved dissolution behavior and oral absorption

A Uchida, K Yuminoki, N Hashimoto, H Sato… - Journal of Drug Delivery …, 2023 - Elsevier
… improved dissolution behavior and enhanced oral absorption … improvement of dissolution
behavior and oral absorption of … improving dissolution behavior and enhancing oral absorption

Understanding the oral absorption of irbesartan using biorelevant dissolution testing and PBPK modeling

N Kaur, PS Thakur, G Shete, R Gangwal… - AAPS …, 2020 - Springer
absorption behavior. This work aims to mechanistically understand the oral absorption behavior
… solubility, supersaturation, and precipitation behavior. Simulations performed using the …