[HTML][HTML] Hyaluronic acid behavior in oral administration and perspectives for nanotechnology-based formulations: A review

AB de Souza, MV Chaud, MHA Santana - Carbohydrate polymers, 2019 - Elsevier
Hyaluronic acid (HA) is a ubiquitous polysaccharide with … ≥10 5 Da orally administered
antagonizes TLR4 overexpression … in the field of the oral HA administration and discussed with …

Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis

M Ricci, GM Micheloni, M Berti, F Perusi… - Musculoskeletal …, 2017 - Springer
… have shown that HA injection and oral administration may have beneficial therapeutic effects
… suggested a combined therapy first with local infiltrations and then with oral composition. …

Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double‐blind, placebo‐controlled study over a 12‐month period

T Tashiro, S Seino, T Sato, R Matsuoka… - The Scientific World …, 2012 - Wiley Online Library
… because a previous study reported that orally administered HA improved knee OA symptoms
… anti-inflammatory drugs were administered orally or externally. HA was administered intra-…

[HTML][HTML] Oral absorption of hyaluronic acid and phospholipids complexes in rats

SL Huang, PX Ling, TM Zhang - World Journal of Gastroenterology …, 2007 - ncbi.nlm.nih.gov
… It has been shown that HA can be absorbed by rats after oral administration in our previous
… exogenous HA when it is administered orally, such as high M r and poor liposolubility of HA. …

Dietary hyaluronic acid migrates into the skin of rats

M Oe, K Mitsugi, W Odanaka, H Yoshida… - The Scientific World …, 2014 - Wiley Online Library
… The results show the possibility that orally administered hyaluronic acid … If orally administered
hyaluronic acid should reach the skin in the form of low-molecular-weight hyaluronic acid, …

Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid

M Šimek, K Turková, M Schwarzer, K Nešporová… - Carbohydrate …, 2023 - Elsevier
… of the absorption of orally administered HA. Furthermore, HA … the mechanism of action of
orally administered HA, it is … , 99m Tc or 14 C labelled) orally administered to rats and dogs was …

Physiochemical properties and application of hyaluronic acid: a systematic review

NM Salwowska, KA Bebenek, DA Żądło… - Journal of cosmetic …, 2016 - Wiley Online Library
… also find ideas that HA orally administered is not absorbed. In … , and elimination of orally
administered HA in rats and dogs. … HA behaves similarly when administered orally to humans. …

Oral administration of hyaluronic acid to improve skin conditions via a randomized double‐blind clinical test

YR Gao, RP Wang, L Zhang, Y Fan… - Skin Research and …, 2023 - Wiley Online Library
Oral administration of HA significantly promoted skin hydration after 2‐8 weeks among both
young and elderly groups. Skin tone improvement was observed after 4‐8 weeks, while an …

Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis

X Cen, Y Liu, S Wang, X Yang, Z Shi, X Liang - Oral Diseases, 2018 - Wiley Online Library
Objective To investigate the therapeutic effect of oral glucosamine ( GS ) as an adjunct to
hyaluronic acid ( HA ) injection on patients with temporomandibular joint osteoarthritis ( TMJ …

Steady state plasma and tissue distribution of low molecular weight hyaluronic acid after oral administration in mice

F Mannino, N Irrera, G Pallio, A Bitto - Natural Product Research, 2024 - Taylor & Francis
… female mice, after its oral uptake. Our results highlighted that hyaluronic acid with a very low
… HA level in plasma at the steady state after oral administration. In the SHAM-HA group, an …