… Key players of the necroptosis signalling pathway are now … Necrostatins may be developed
as potent inhibitors of necroptosis, … of necroptosis in specific injury of different organs, and the …

… organ fibrosis. In this review, we summarize the role of necroptosis signalling in organ
fibrosis and collate the small molecule compounds targeting necroptosis. In addition, we …

… the contribution of necroptosis and associated signaling regulators, such as RIPK3, to human
diseases involving inflammation or organ injury. The complex role of necroptosis signaling …

… Regulated forms of necrosis are executed by death receptor … underlying necroptosis, the
functions of necroptosis-associated … (ALI), sepsis/systemic inflammatory associated organ injury, …

… Recently, necroptosis was reported to mediate organ rejection in both cardiac and renal …
of the pathogenesis of necroptosis-associated diseases. In addition, necroptosis regulators …

… , which can trigger RIPK3-dependent immune responses, 68 suggesting the possibility
that HMGB1 release also may induce necroptosis in these other organs. In addition, the …

… organ dysfunction and cause lasting tissue injury in the kidney. Despite evidence of a link
between necroptosis … implicates a role for necroptosis in the pathogenesis of kidney diseases, …

… , and it seems that necroptosis inhibition can reduce the side effects of chemicals. Here we
introduce mechanism and pathogenesis of necroptosis as an emerging molecular pathway, …

… , and clinical studies that implicates necroptosis in the pathogenesis of ARDS. Lastly, we …
This work suggests that, in the controlled setting of organ transplant, necroptosis may be a …

… uniquely associated with induction of necroptosis, however recent evidence … necroptosis
identification and discuss past and recent data to provide an update of the so-called “necroptosis…