… , primary tumor resection resulted in slower disease progression and longer survival in
an orthotopic mouse model of metastatic prostate cancer. In future studies, this model will be …

… Here, we report the establishment of a simple and yet sensitive procedure of primary
tumor transplant, surgical removal of primary tumor and bioluminescence imaging-based …

… Our results are based on a mouse model, … orthotopic surgical implantation in immune-intact
mice as an appropriate translational model to evaluate the role of primary tumor resection …

… orthotopic mouse models of human colon cancer expressing a fluorescent protein. Tumors
were resected under bright light surgery (… For primary tumor resection, the cecal stump was …

… orthotopic implantation (OS) and subcutaneous implantation (SQ) are commonly used to
generate murine models to investigate cancer. … primary tumor resection in SQ and OS models. …

… In the conservative setting, median primary tumor weight was … setting after surgical resection
of the primary tumor, treatment … used a purely murine model of pancreatic cancer, and little is …

… Weigh the recipient nude mouse for orthotopic surgery, and anesthetize the animal by
intraperitoneal administration of the prepared ketamine/xylazine solution at a dose of 10 μl/mg. …

… Resections were performed 4 weeks after primary tumor engraftment. All animals received
… guide for the removal of OS tumors in our validated orthotopic mouse model. We found that …

… The primary tumor burden at termination was significantly less with FGS compared with BLS:
19.3 ± 5.3 mm 2 vs 6.2 ± 3.6 mm 2 , p = 0.048. FGS resulted in significantly longer disease-…

… In most of the mice that underwent surgical resection, the primary tumor was totally
removed according to the clear absence of a luciferase signal around the liver area (Fig. 1C,D). …