… a novel orthotopic implantation model of human prostate cancer (PCa). As PCa … murine
model of human PCa metastasis. In this model, the human PCa cell lines PC3-M is orthotopically …

… This study applied an innovative orthotopic mouse model to study the effects of primary
tumor resection in oligometastatic prostate cancer. A beneficial effect of this intervention on …

… Understanding the mechanism of prostate cancer metastasis is essential to the design of a
… such a model by using orthotopic implantation of human prostate cells in BALB/c nude mice. …

… In conclusion, the orthotopic prostate cancer metastasis model … of mechanisms underlying
prostate cancer metastasis and … this model may also be suitable for developing orthotopic …

… Transgenic mouse models of prostate cancer have been developed in which the rat … of an
orthotopic model of primary prostate cancer and lymph node metastasis in immunocompetent …

… xenograft mouse model [7]. The present study used, for the first time, an orthotopic PCa
mouse model, which resulted not only in tumor growth in the prostate but also in metastases to …

… PC3M-LN4 cells have been well characterized in the orthotopic implantation model of
prostate cancer progression by our laboratory and others, so the conditions for development of …

… tumor models versus orthotopic models [… metastatic cells can be generated from an orthotopic
route of tumor initiation. We directly compared orthotopic versus sc metastasis in our model …

… We demonstrate using complex human xenograft mouse models of orthotopic and metastatic
PCa that, contrary to previous reports, KLK4 expression in advanced disease does not …

… model can annotate drug targets of clinical relevance and is a valuable tool to study prostate
cancer … procedure to establish a human orthotopic prostate cancer xenograft mouse model. …