Anti-metastatic effects of liposomal gemcitabine in a human orthotopic LNCaP prostate cancer xenograft model

P Jantscheff, V Ziroli, N Esser, R Graeser… - … experimental metastasis, 2009 - Springer
spread rather than from primary tumor burden. Here, we monitored growth and metastatic
spread of an orthotopic luciferase/GFP-expressing LNCaP PCa xenograft model in SCID mice …

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

H Liu, MR Patel, JA Prescher… - Proceedings of the …, 2010 - National Acad Sciences
cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer
orthotopic models … These models recapitulate human cancer features not captured with previous …

Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model

GG Hillman, Y Wang, O Kucuk, M Che… - Molecular cancer …, 2004 - AACR
… in a preclinical model of prostate carcinoma in vivo. We used an orthotopic prostate carcinoma
model … Systemic interleukin 2 therapy for human prostate tumors in a nude mouse model. …

Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases

H Uehara, SJ Kim, T Karashima… - … the National Cancer …, 2003 - academic.oup.com
… kinase, are associated with the growth of metastatic prostate tumor cells in the bone parenchyma.
… in a mouse model of prostate cancer metastasis. Methods: Human prostate cancer PC-…

The TRAMP mouse as a model for prostate cancer

AA Hurwitz, BA Foster, JP Allison… - Current protocols in …, 2001 - Wiley Online Library
… autochthonous (orthotopic) prostate tumors … on prostate tumor metastasis, we recently
introduced an immunocompetent murine model that nominally recapitulates clinical metastatic

[HTML][HTML] SPARCL1 suppresses metastasis in prostate cancer

Y Xiang, Q Qiu, M Jiang, R Jin, BD Lehmann… - Molecular …, 2013 - Elsevier
mouse models to analyze the impact of SPARCL1 on prostate cancer cell growth and metastasis
… /SPARCL1 cells into a mouse prostate (orthotopic xenograft [OX] model), (Figure 4) and …

The role of platelet-derived growth factor in prostate cancer development and progression depends on organ site of involvement in an orthotopic mouse model

J Papadopoulos, SJ Kim, JS Kim, SW Kim, M Maya… - Cancer Research, 2008 - AACR
… the location of metastases. We utilized an orthotopic human prostate cancer animal model to
… Single clones were isolated from the human prostate cancer cell line PC-3P. Basal levels of …

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis

S Shankar, S Ganapathy, RK Srivastava - Clinical Cancer Research, 2008 - AACR
… It is therefore essential to show the efficacy of sulforaphane and TRAIL in a suitable mouse
model before the clinical potential of this combination regimen is established. The study of …

[HTML][HTML] In vitro and in vivo model systems used in prostate cancer research

D Cunningham, Z You - Journal of biological methods, 2015 - ncbi.nlm.nih.gov
… the development of murine models that allow for the investigation of tumorigenic and metastatic
processes. Current … Orthotopic xenograft models allow for the introduction of cancerous …

Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2

PH Killian, E Kronski, KM Michalik, O Barbieri… - …, 2012 - academic.oup.com
… In an orthotopic mouse model of hematogenous metastasis, … highly aggressive PC-3
prostate cancer cells in a murine model of hematogenous metastasis and identified the molecular …