… of experimental osteoarthritis that YAP activation by … YAP in OA pathogenesis in vivo, we
first generated Mst1 f/f ;Mst2 f/f ;Col2a1-Cre mutant mice in which Hippo signaling is inactivated …

… and ameliorate osteoarthritis symptoms in mouse models. We propose that the YAP–… The
cytoplasmic localization of TAZ underlays its inactivation in hMSCs, whereas nuclear YAP was …

… ; Col2a1-Cre mutant mice in which Hippo signalling is inactivated in chondrocytes to elucidate
the function of YAP in OA pathogenesis. The expression of YAP was strongly upregulated …

… Inactivation of Hippo/YAP1 signaling pathway by Verteporfin is … that Hippo/YAP1 is of great
importance for osteophyte formation. … In conclusion, Hippo/YAP1 inactivation by verteporfin is …

… YAP was upregulated in human and mice osteoarthritis … YAP expression in osteoarthritis and
normal articular cartilage and … assay of YAP expression in normal and ACLT mice 8 and 16 …

… ShcA retains p-YAP1 in the cytosol … − mice, we found a significant decrease in p-YAP1
expression in ShcA deficient cells (−0.9874 [−1.519 to −0.04967]) with no alteration in total YAP1 …

… that YAP was also significantly activated in mice OA development, and conditional knockout
(cKO) of YAP in mice … phosphorylation leads to YAP/TAZ degradation and inactivation in the …

… the expression of Yap1 mRNA by inactivating the Yap1 promoter … YAP1 is a potential and
common target for osteoarthritis … of YAP1 protein was downregulated in mouse osteoarthritis …

… degradation of YAP/TAZ [9]. Conversely, inactivation of the Hippo pathway increases YAP/TAZ …
promotes RA FLS invasiveness in vivo and arthritis severity in mice, and inhibition of YAP …

… This study aimed to investigate the protective effects of OLA on OA in rats via the Hippo/YAP
and Wnt/β-catenin pathways and explain its possible mechanisms. On this basis, useful …