… Impairment of mineralization and widening of the growth plates have been reported in a
13-year-old boy who received pamidronate at a dose similar to those we used in the present …

… In conclusion, cyclical pamidronate infusions markedly improve bone density and decrease
fracture rate in severely affected OI patients less than 2 yr of age without causing major …

… pamidronate improves the clinical course in children and adolescents with osteogenesis
imperfecta (OI)… and after pamidronate infusions, requiring close monitoring especially at the first …

… In patient 2 we observed the complete disappearance of new fracture episodes after the
beginning of pamidronate infusions. After 18 months, the treatment was interrupted for the first …

… pamidronate infusions increase bone mass in children suffering from osteogenesis imperfecta…
patients before and after 2.4 ± 0.6 years of pamidronate treatment (age at the time of the …

… and fever may accompany the initial pamidronate infusion cycle in infants with severe OI …
report, the temporal association between the initial pamidronate infusion and the onset of the …

… This study confirms that pamidronate in cyclic infusions is an effective treatment in children
with OI by decreasing two of the most debilitating factors of their disease: fractures and pain. …

… However, given the nonlinear relationship of DXA improvement and dose, it is less … dose
of pamidronate used in this study, markers of bone formation were stable before each infusion …

… Pamidronate (PAM) infusion is the standard treatment in children with osteogenesis imperfecta
… with higher potency and faster intravenous infusion, but its efficacy and safety has not …

… Whereas pamidronate infusions were generally well tolerated, we have observed cases of
acute respiratory compromise in babies with pre‐existing pulmonary problems who received …