MicroRNAs in ovarian cancer biology and therapy resistance

MTM van Jaarsveld, J Helleman, EMJJ Berns… - The international journal …, 2010 - Elsevier
… The management of ovarian cancer has improved over the last 20 years due to more effective
… These studies suggest that targeting of let-7 in ovarian cancer is feasible and might lead to …

Role of microRNAs in drug-resistant ovarian cancer cells

A Sorrentino, CG Liu, A Addario, C Peschle… - Gynecologic …, 2008 - Elsevier
… of advanced ovarian cancer, but a successful long-term treatment is prevented by … non-coding
RNAs, microRNAs (miRNAs) in cancer development, with several … miRNA target prediction …

MicroRNA‐mediated drug resistance in ovarian cancer

A Mihanfar, A Fattahi… - Journal of cellular …, 2019 - Wiley Online Library
… markers, as well as novel therapeutic targets to overcome resistance in ovarian cancer. …
(MDR) is one of the main hurdles against successful and complete treatment of ovarian cancer. …

[HTML][HTML] The potential of MicroRNAs as clinical biomarkers to aid ovarian cancer diagnosis and treatment

M Davies, MG Davey, N Miller - Genes, 2022 - mdpi.com
… This research is still at a preliminary stage, and although initial studies are important in order
to identify candidate miRNA targets for investigation, the small sample sizes often bring the …

[HTML][HTML] Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

A Kandettu, D Adiga, V Devi, PS Suresh… - Genes & …, 2022 - Elsevier
… profiling of miRNAs can be employed for the clinical management of OC. … and cancer
dissemination by targeting MTDH (metadherin) in HGSOCs (high grade serous ovarian cancer) via …

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
cancer types, including neuroblastoma, ovarian cancerovarian cancer, an integrated
network analysis of potential mRNA target expression revealed miR-506 as one of the miRNAs

Tumor-targeting, microRNA-silencing porous silicon nanoparticles for ovarian cancer therapy

A Bertucci, KH Kim, J Kang, JM Zuidema… - … applied materials & …, 2019 - ACS Publications
… To our knowledge, this is the first report of effective in vivo treatment of ovarian cancer
leveraging an anti-miR-21 therapeutic agent. Looking forward, more complex models of …

[HTML][HTML] Epigenetic biomarkers in the management of ovarian cancer: current prospectives

A Singh, S Gupta, M Sachan - Frontiers in cell and developmental …, 2019 - frontiersin.org
miRNA signatures that could distinguish ovarian tumors … prognostic relevance of several
miRNAs, their association with … well as therapeutic target for ovarian cancer management. For …

Updates and current challenges in microRNA research for personalized medicine in ovarian cancer

V Mandilaras, M Vernon… - Expert Opinion on …, 2017 - Taylor & Francis
miRNAs is an innovative and promising field for the diagnosis and treatment of ovarian cancer
, each mRNA may be targeted by several different miRNAs, leading to complex regulatory …

MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

N Yang, S Kaur, S Volinia, J Greshock, H Lassus… - Cancer research, 2008 - AACR
… , and treatment of this disease. Here, we used miRNA microarray on 69 ovarian tumor
specimens to identify the … Up to one-third of human mRNAs seem to be miRNA targets (41). Each …