Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
… Besides summarizing the genetic factors linked to PCOS, we highlight epigenetic
modulation as a mechanism that bridges early-life exposures and subsequent phenotypes in …

Polycystic ovary syndrome: the epigenetics behind the disease

MC Eiras, DP Pinheiro, KAM Romcy, RA Ferriani… - Reproductive …, 2022 - Springer
… etiology of this syndrome [11]. This suggests a complex and multifactorial origin of PCOS,
in which genetic alterations, environmental factors, and epigenetic modifications contribute to …

Modulation of the inflammatory response in polycystic ovary syndrome (PCOS)—searching for epigenetic factors

D Szukiewicz, S Trojanowski, A Kociszewska… - International journal of …, 2022 - mdpi.com
ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive
age. Despite its incidence, the syndrome … , endocrine, and behavioral factors. Primary clinical …

Polycystic ovary syndrome-epigenetic mechanisms and aberrant microRNA

IR Ilie, CE Georgescu - Advances in clinical chemistry, 2015 - Elsevier
… is highly heterogeneous and it is not yet clear which factorsfactors can modify the clinical
presentation via epigenetic … This review examines the role of epigenetics and miRNA in …

Epigenetic and transcriptional alterations in human adipose tissue of polycystic ovary syndrome

M Kokosar, A Benrick, A Perfilyev, R Fornes… - Scientific reports, 2016 - nature.com
… Genetic and epigenetic factors may predispose women to polycystic ovary syndrome (PCOS)…
and epigenetic changes in adipose tissue that are relevant for development of the disease. …

The role of genetics, epigenetics and lifestyle in polycystic ovary syndrome development: the state of the art

V Bruni, A Capozzi, S Lello - Reproductive Sciences, 2022 - Springer
… of major genetic, epigenetic and environmental factors on the appearance of this … epigenetics
in the appearance of PCOS. Several genes, including those related to adrenal and ovarian

Epigenetic abnormality: a possible mechanism underlying the fetal origin of polycystic ovary syndrome

Z Li, H Huang - Medical hypotheses, 2008 - Elsevier
… Given that the development and inheritance of other adult diseases with fetal origin, which
can be induced by nutritional or environmental factors in utero, usually involves an epigenetic

[HTML][HTML] Characterization of DNA methylation and screening of epigenetic markers in polycystic ovary syndrome

P Cao, W Yang, P Wang, X Li… - Frontiers in cell and …, 2021 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a … ovary. Although the etiology of PCOS is largely
unknown, many studies suggest that aberrant DNA methylation is an important contributing factor

[PDF][PDF] Role of epigenetic modifications in the aberrant CYP19A1 gene expression in polycystic ovary syndrome

E Hosseini, M Shahhoseini, P Afsharian… - Archives of Medical …, 2019 - termedia.pl
… genetic and epigenetic alter… factors in the etiopathogenesis of this syndrome [3, 4]. Although
its exact etiology is poorly understood, some evidence suggests that epigenetic factors are …

[HTML][HTML] Introduction: determinants of polycystic ovary syndrome

R Azziz - Fertility and sterility, 2016 - Elsevier
… (eg, gene variants, epigenetic, and race/ethnicity) factors. Finally a … additional insight into
those factors determining the etiology, … Epigenetics in polycystic ovary syndrome: a pilot study of …