Characterization of DNA methylation and screening of epigenetic markers in polycystic ovary syndrome

P Cao, W Yang, P Wang, X Li… - Frontiers in cell and …, 2021 - frontiersin.org
… , we focused on ovarian GCs to investigate the epigenetic regulatory mechanism of PCOS. …
methylation characteristics and screened potential epigenetic markers. We identified several …

Polycystic ovary syndrome: the epigenetics behind the disease

MC Eiras, DP Pinheiro, KAM Romcy, RA Ferriani… - Reproductive …, 2022 - Springer
… Altered DNA methylation is the main reported epigenetic marker in developmental epigenetic
reprogramming of PCOS. These modifications lead to gene silencing or reduction of its …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
… is germline transmission of epigenetic markers. Intergenerational and transgenerational …
, as the whole ovary was sequenced in this study, whether these effects result from epigenetic

Modulation of the inflammatory response in polycystic ovary syndrome (PCOS)—searching for epigenetic factors

D Szukiewicz, S Trojanowski, A Kociszewska… - International journal of …, 2022 - mdpi.com
… patients, elevated values of inflammatory markers or their gene markers have been reported.
Epigenetic modulation of androgenic activity in response to inflammatory signaling is also …

[HTML][HTML] Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process

NEH Mimouni, I Paiva, AL Barbotin, FE Timzoura… - Cell metabolism, 2021 - cell.com
… of DNA methylation and propose methylome markers as a possible diagnostic landmark
for the condition, while also identifying potential candidates for epigenetic-based therapy. …

[PDF][PDF] Role of epigenetic modifications in the aberrant CYP19A1 gene expression in polycystic ovary syndrome

E Hosseini, M Shahhoseini, P Afsharian… - Archives of Medical …, 2019 - termedia.pl
… infertile polycystic ovary syndrome (PCOS) patients and the correlation of these epigenetic
modifications with the expression of the ovarian aromatase gene (as an important marker in …

Epigenetic marks in polycystic ovary syndrome

AB Motta - Current Medicinal Chemistry, 2020 - ingentaconnect.com
… Moreover, the determination of genetic markers may increase the … markers available to
date. Thus, the aim of this review is to provide updated information on these epigenetic marks (mi…

Deciphering the DNA methylome of polycystic ovary syndrome

Q Tan - Molecular Diagnosis & Therapy, 2020 - Springer
… PCOS from disease etiology to epigenetic marker discovery. Current epigenetic studies have
provided convincing observational evidence linking epigenetic regulation with PCOS origin…

Polycystic ovary syndrome-epigenetic mechanisms and aberrant microRNA

IR Ilie, CE Georgescu - Advances in clinical chemistry, 2015 - Elsevier
… the clinical presentation via epigenetic modifications. MicroRNA (… This review examines the
role of epigenetics and miRNA in the … increased expression of the proliferation marker PCNA. …

DNA methylation in the pathogenesis of polycystic ovary syndrome

ER Vázquez-Martínez, YI Gómez-Viais… - …, 2019 - rep.bioscientifica.com
… (and other epigenetic marks) in the peripheral blood is the fact that the total DNA is isolated
from different cell types with their DNA methylation profile, whose content and epigenetic