MGMT promoter methylation testing to predict overall survival in people with glioblastoma treated with temozolomide: a comprehensive meta-analysis based on a …

S Brandner, A McAleenan, C Kelly, F Spiga… - Neuro …, 2021 - academic.oup.com
… However, MGMT methylation status does not always … MGMT promoter methylation improves
response to alkylating therapy is still unknown. MGMT promoter methylation status testing is …

[HTML][HTML] Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM

N Shah, B Lin, Z Sibenaller, T Ryken, H Lee, JG Yoon… - PloS one, 2011 - journals.plos.org
… ) test based on the 3R classification and show that this test is both feasible in the clinical setting
and predictive of progression free survival … of a test based on this promoter-wide analysis …

Prognostic value of test (s) for O6‐methylguanine–DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma …

A McAleenan, C Kelly, F Spiga… - Cochrane Database …, 2021 - cochranelibrary.com
… In this Cochrane Review, we aimed to assess which way of measuring methylation of the
MGMT promoter best predicts survival for people with glioblastoma who are treated with …

MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges

A Mansouri, LD Hachem, S Mansouri, F Nassiri… - Neuro …, 2019 - academic.oup.com
… Hegi et al observed that even among unmethylated patients treated with radiation and TMZ,
progression-free survival (PFS) was significantly improved, while increase in overall survival

The utilization of MGMT promoter methylation testing in United States hospitals for glioblastoma and its impact on prognosis

A Lee, I Youssef, VW Osborn, J Safdieh… - Journal of Clinical …, 2018 - Elsevier
overall survival (OS) by coding status of MGMT promoter … patterns of MGMT promoter
methylation testing using the … ) to analyze completeness of coding for MGMT as well as to compare …

MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide: A Pooled Analysis of Four Clinical …

ME Hegi, E Genbrugge, T Gorlia, R Stupp… - Clinical Cancer …, 2019 - AACR
… the extent of MGMT promoter methylation and overall survival (OS). … MGMT promoter
methylation data was obtained from four trials for newly diagnosed GBM, with central MGMT testing

Correlation of the quantitative level of MGMT promoter methylation and overall survival in primary diagnosed glioblastomas using the quantitative MethyQESD method

C von Rosenstiel, B Wiestler, B Haller… - Journal of clinical …, 2020 - jcp.bmj.com
… focuses on comparing MGMT promoter methylation status of various patients with their survival
time of … Associations of clinical data and MGMT promoter status were tested by χ 2 tests. …

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

M Weller, R Stupp, G Reifenberger… - Nature Reviews …, 2010 - nature.com
… and overall survival in WHO grade III anaplastic glioma patients with MGMT promoter
methylation, … In other words, the test needs to predict overall dense promoter methylation that is …

[HTML][HTML] The prognostic value of MGMT promoter status by pyrosequencing assay for glioblastoma patients' survival: a meta-analysis

H Zhao, S Wang, C Song, Y Zha, L Li - World journal of surgical oncology, 2016 - Springer
… ) for overall survival (OS) and the progression-free survival (… of MGMT promoter methylation
among GBM was assessed. … , direct testing status of MGMT promoter methylation might be …

Association of MGMT promoter methylation status with survival outcomes in patients with high-risk glioma treated with radiotherapy and temozolomide: an analysis …

EH Bell, P Zhang, BJ Fisher, DR Macdonald… - JAMA …, 2018 - jamanetwork.com
… correlated with progression-free and overall survival on … Meaning The results of this study
suggest that MGMT promoter methylation … in 135 of the 150 tumors tested (90.0%). To date, no …