Epi-nutrients in the oviductal environment: Folate levels and differential gene expression of its receptors and transporters in the bovine oviduct

EV García, ME Oliva, JG LeBlanc, AD Barrera - Theriogenology, 2018 - Elsevier
… of physiological levels of folate in the bovine oviductal environment merits further investigation
in order to better understand the role of this micronutrient in the oviductal physiology and …

Impact of extracellular folic acid levels on oviductal gene expression

EV García, MJ Mansilla, JG LeBlanc, AD Barrera - Theriogenology, 2020 - Elsevier
folate in the oviduct remain unknown. The present study aimed to assess the effect of folic acid
(FA) on expression levels … little information about its role in the oviductal environment. The …

Prenatal exposure to environmentally-relevant contaminants perturbs male reproductive parameters across multiple generations that are partially protected by folic …

M Lessard, PM Herst, PL Charest, P Navarro… - Scientific reports, 2019 - nature.com
… plus oviducts were collected in 37 C M2 medium (Sigma, M7167). Using a pre-heated IVF
Work Station (Origio Midatlantic Devices, NJ, USA), ovaries were separated from oviducts and …

Multigenerational effects of abnormal folate metabolism on embryo growth and development

K Menelaou - 2020 - repository.cam.ac.uk
… However, Mtrr deficiency in the placenta cells themselves alters the transcriptome. In summary,
abnormal folate metabolism caused by the Mtrrgt mutation affects the uterine environment

Physiological aspects of female fertility: role of the environment, modern lifestyle, and genetics

RJ Hart - Physiological reviews, 2016 - journals.physiology.org
… maybe increased. The association of bisphenol A (BPA) as a potential environmental cause
of … Not only is the systemic and follicular environment different in PCOS, the gene expression …

Nutrient concentrations in murine follicular fluid and the female reproductive tract

SE Harris, N Gopichandran, HM Picton, HJ Leese… - Theriogenology, 2005 - Elsevier
Oviductal pyruvate concentration was significantly higher, … , with highest levels being found
in the oviduct. The follicular … metabolism and of nutritional environments of the oocyte and …

Parental diet, pregnancy outcomes and offspring health: metabolic determinants in developing oocytes and embryos

KD Sinclair, AJ Watkins - Reproduction, fertility and development, 2014 - CSIRO Publishing
… plasma components that act on oviductal and uterine tissues. … -made αMEM with methionine,
folate, vitamins B 12 and B 6 … of manipulating the maternal environment is well defined, the …

Impact of the periconceptional environment on the programming of adult disease

AJ Watkins, ES Lucas, TP Fleming - Journal of developmental origins …, 2010 - cambridge.org
oviductal and uterine environments that match precisely the needs of the developing
embryo,66,67 with oviductal … nonphysiological levels of some nutrients, such as methyl-folate cycle …

Effects of breed, parity, and folic acid supplement on the expression of folate metabolism genes in endometrial and embryonic tissues from sows in early pregnancy

M Vallée, F Guay, D Beaudry, J Matte… - Biology of …, 2002 - academic.oup.com
Folic acid and glycine are factors of great importance in early gestation. In sows, folic acid …
, the most abundant amino acid in the sow oviduct, uterine, and allantoic fluids, is reported to …

Disruption of folate metabolism causes poor alignment and spacing of mouse conceptuses for multiple generations

AL Wilkinson, K Menelaou, J Rakoczy… - Frontiers in Cell and …, 2021 - frontiersin.org
Abnormal uptake or metabolism of folate increases risk of human pregnancy complications,
though the mechanism is unclear. Here, we explore how defective folate metabolism …