Involvement of LDL and ox-LDL in cancer development and its therapeutical potential

CF Deng, N Zhu, TJ Zhao, HF Li, J Gu, DF Liao… - Frontiers in …, 2022 - frontiersin.org
… It is worth mentioning that cholesterol is the precursor for steroid hormones, bile acids, vitamin
D, and oxysterols, and acts as a key material for cell growth (10). Low-density lipoprotein (…

Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of …

L Cominacini, AF Pasini, U Garbin, A Davoli… - Journal of Biological …, 2000 - ASBMB
oxidized low density lipoprotein (ox-LDL) on the intracellular production of reactive oxygen
species (ROS) in bovine aortic endothelial cells … receptor lectin-like ox-LDL receptor-1 (LOX-1)…

Role of Ox-LDL and LOX-1 in Atherogenesis

AJ Kattoor, SH Kanuri, JL Mehta - Current medicinal chemistry, 2019 - ingentaconnect.com
… : Oxidized LDL (ox-LDL) plays a central role in atherosclerosis by acting on multiple cells
such as endothelial cells, … and epidermal growth factor (EGF) are induced by oxLDL causing …

Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells

JL Mehta, DY Li - Biochemical and biophysical research communications, 1998 - Elsevier
… Microvascular endothelium growth medium consisted of 500 ml of endothelial cell basal …
endothelial cell possess abundant endothelial receptor for ox-LDL (LOX-1). Ox-LDL upregulates …

Stimulation of smooth muscle cell proliferation by ox-LDL-and acetyl LDL-induced macrophage-derived foam cells

CM Shen, SJT Mao, GS Huang, PC Yang, RM Chu - Life sciences, 2001 - Elsevier
… Contrary effects of lightly and strongly oxidized LDL with potent promotion of growth versus
apoptosis in arterial smooth muscle cells, macrophages, and fibroblasts. Arterioscler Thromb …

The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an …

L Cominacini, A Rigoni, AF Pasini, U Garbin… - Journal of Biological …, 2001 - ASBMB
… In this study we examined the effect of ox-LDL on the intracellular NO … cells and whether
this effect is influenced by ox-LDL binding to the endothelial receptor lectin-like ox-LDL receptor-…

OxLDL stimulates cell proliferation through a general induction of cell cycle proteins

ME Zettler, MA Prociuk, JA Austria… - American Journal …, 2003 - journals.physiology.org
… proliferation of cells within the vessel wall (41). In vitro, mildly oxidized LDL is capable of …
Therefore, oxLDL released cells from growth arrest in a time- and dose-dependent manner. …

Ox-LDL induces endothelial cell apoptosis via the LOX-1-dependent endoplasmic reticulum stress pathway

D Hong, YP Bai, HC Gao, X Wang, LF Li, GG Zhang… - Atherosclerosis, 2014 - Elsevier
ox-LDL-induced endothelial cell apoptosis, we examined whether LOX-1 mediates ox-LDL-induced
apoptosis in endothelial cells … mitigate ox-LDL-induced endothelial cell apoptosis …

Effects of oxLDL on number and activity of circulating endothelial progenitor cells

X Wang, J Chen, Q Tao, J Zhu… - Drug and chemical …, 2004 - Taylor & Francis
… We hypothesized that oxLDL not only directly injured endothelial cell but also affected EPCs
… the numbers and activity of endothelial progenitor cells exposed to oxLDL in this study. …

Oxidized LDL modulates Bax/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells

H Kataoka, N Kume, S Miyamoto… - … , and vascular biology, 2001 - Am Heart Assoc
… Several lines of evidence have suggested that oxidized LDL (Ox-LDL) … Ox-LDL can bind to
scavenger receptors and subsequently be internalized by macrophages, resulting in foam cell