… in colorectal cancer (CRC) holds potential for therapeutic intervention. We hypothesized that
it can be modulated by oxicams, a class of … of classic and new oxicam analogues. Arginine …

… to determine whether classic oxicams (piroxicam and meloxicam) and their novel … oxicam
class of NSAIDs labeled with reduced gastrotoxicity, differing from piroxicam and meloxicam …

… If cyclooxygenase-2 is a relevant target of NSAIDs, then another class of COX-2 inhibitors
should also be effective at inhibiting tumor growth. To test this hypothesis we used …

… , lung, and stomach cancer (5). Piroxicam is a NSAID of the oxicam class used as an analgesic
… : Inhibition of COX2 in colon cancer modulates tumor growth and MDR1 expression to …

… to identify new classes of molecules devoid … colorectal cancer cells exhibited an increased
susceptibility to apoptosis after exposure to selective COX2 inhibitors (9). In colorectal cancer …

… The pH of the colon varies from 6.4–7.0, thus in order to maintain the micro-environmental
pH of the tablet above 7.0 and hence to achieve a pH-independent drug release two classes …

… drugs, including oxicams—a class of nonsteroidal anti-… In colorectal cancer cells, the number
of HSPA1 and … protein can be altered by novel oxicam analogues containing arylpiperazine …

… cells were more sensitive to the cytotoxic effects of profens, while the viability of cervical
and colon carcinoma cells was more significantly affected by the oxicams. The IC50 values of …

… Oxicams belong to a class of non-steroidal anti-inflammatory drugs (NSAIDs). Antitumor
potential of commonly used non-steroidal anti-inflammatory drugs is currently often reported in …

… piroxicam reduced the incidence and multiplicity of rat intestinal tumors more effectively than
DFMO or piroxicam … , the numbers of polyps in all size classes were reduced at the same …