… Consequently, another property of basal ganglia neurons appears to be responsible for
their selective vulnerability in HD. The proposition that defects in mitochondrial energy …

… and non-dopaminergic neurons in SN was observed. The CS showed increased total
superoxide dismutase activity but no increase in LP or neuron damage, suggesting a greater …

… Mn-induced neuronal injury in basal ganglia in vitro. We exposed basal ganglia neurons with
50 … Taken together, these results showed that PAS-Na could protect basal ganglia neurons …

… in slow excitotoxic neuronal death, by making neurons more … for oxidative damage and
mitochondrial energy dysfunction … in lactate levels in the basal ganglia of HL) patients (increased …

… Previous studies in this and other laboratories show that high glucose induces PCD in
neurons both in vivo and in vitro (2–6). In primary dorsal root ganglion neurons (DRG) from …

… Mn-induced motor dysfunction and neuronal loss. In conclusion, Mn treatment resulted in
motor dysfunction and neuronal loss, possibly involving an interaction between oxidative stress …

… toxicity, oxidative stress resulting from energy impairment may serve as a link among
neuronal … For that reason, we examinedwhether oxidative stress plays a role in glutamate-mediated …

… dysfunction, excitotoxic processes, and oxidative stress. Importantly, the recent development
of transgenic mouse models of HD led to the identification of neuronal … ganglia neurons are …

… in the spinal cord (SC) and dorsal root ganglia. The frataxin is evident to regulate iron handling
… This is the major cause of neuronal dysfunction and nerve injury, ultimately the cognitive …

… After the addition of 100 µM oxidized cytochrome c, the reaction was followed for 2 min at
550 nm. The reduction of oxidized cytochrome c was assayed by an increase in absorbance. …