Oxidative stress and aberrant signaling in aging and cognitive decline

W Dröge, HM Schipper - Aging cell, 2007 - Wiley Online Library
… In this review, we summarize recent findings suggesting that the age-related increase in
oxidative stress may have a direct impact on the insulin signaling pathway and downregulate …

Oxidative damage and age-related functional declines

I Martin, MS Grotewiel - Mechanisms of ageing and development, 2006 - Elsevier
… Assuming that increased resistance to oxidative stress leads to a reduced accumulation
of oxidative damage in aging methuselah flies, this finding suggests that senescence of the …

[PDF][PDF] Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging

YH Wei, SB Wu, YS Ma, HC Lee - Chang Gung Med J, 2009 - cgmj.cgu.edu.tw
… peroxide (H2O2) and oxidative damage to DNA in the tissue … function decline and increase
in the production of the ROS in mitochondria, accumulation of mtDNA mutation and oxidative

Iron accumulation with age, oxidative stress and functional decline

J Xu, MD Knutson, CS Carter, C Leeuwenburgh - PloS one, 2008 - journals.plos.org
… We investigated non-heme iron concentration, oxidative stress to nucleic acids in …
oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects. …

Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study

I Hajjar, SS Hayek, FC Goldstein, G Martin… - Journal of …, 2018 - Springer
… Since cardiovascular risk factors are also associated with a decline in executive function, we
hypothesized that aminothiol markers of OS will be predictive of cognitive decline in healthy …

Cognitive decline is associated with systemic oxidative stress: the EVA study

C Berr, B Balansard, J Arnaud… - Journal of the …, 2000 - Wiley Online Library
… relationship between blood oxidative stress markers and cognitive decline over a 4 year
period in a large population-based cohort. The oxidative stress markers included levels of …

Oxidative stress, frailty and cognitive decline

J Mulero, P Zafrilla, A Martinez-Cacha - The journal of nutrition, health & …, 2011 - Springer
… we will see how oxidative stress is a common factor in the frailty and cognitive decline. …
between a) oxidative stress and frailty, b) oxidative stress and decline cognitive. Results: the …

Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

JE Kokoszka, P Coskun, LA Esposito… - Proceedings of the …, 2001 - National Acad Sciences
decline in mitochondrial function in the heterozygote was associated with the compensatory
up-regulation of oxidative … species production, oxidative stress, functional decline, and the …

Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice

Y Zhang, KE Fischer, V Soto, Y Liu… - Archives of biochemistry …, 2015 - Elsevier
… if the functional declines with age or even the shortening of lifespan in high fat-fed mice
we report here could be mitigated through the reduction of oxidative stress and/or damage. …

Oxidative stress and aging: beyond correlation

TR Golden, DA Hinerfeld, S Melov - Aging cell, 2002 - Wiley Online Library
… Age-related declines in cognitive function in humans are of increasing concern as … of
oxidative stress in such declines and the ability of antioxidants to help maintain cognitive functions. …