Oxidative stress and apoptosis

K Kannan, SK Jain - Pathophysiology, 2000 - Elsevier
… All the three functional phases of apoptosis are under the influence of regulatory controls.
Thus, increasing evidences provide support that oxidative stress and apoptosis are closely …

Signalling mechanisms and oxidative stress in apoptosis

AFG Slater, C Stefan, I Nobel… - Toxicology letters, 1995 - Elsevier
… As GSH depletion will lower a cell‘s capacity to buffer against endogenous oxidants, we
propose that it contributes to the increased oxidative damage commonly observed to …

Oxidative stress in apoptosis and cancer: an update

JM Matés, JA Segura, FJ Alonso, J Márquez - Archives of toxicology, 2012 - Springer
… regulated apoptotic pathways that involve oxidative stress … to both unbalance in apoptosis
and development of cancer. … the increased resistance of tumor cells to undergo apoptosis, …

Oxidative stress–induced apoptosis of endothelial cells

MC Warren, EA Bump, D Medeiros… - Free Radical Biology and …, 2000 - Elsevier
… We used menadione to simulate a common physiological form of oxidative stress: an increase
in intracellular production of O 2 • − . We elected to use menadione sodium bisulfite (MSB) …

Oxidative stress and apoptosis: impact on cancer therapy

T Ozben - Journal of pharmaceutical sciences, 2007 - Elsevier
… the oxidative damage. This review will address some of the current paradigms of oxidative
stress, and antioxidants on apoptosis, … cells are under increased oxidative stress compared to …

Triggering and modulation of apoptosis by oxidative stress

J Chandra, A Samali, S Orrenius - Free radical biology and medicine, 2000 - Elsevier
… Also, NO radical dot has been reported to induce apoptosis by increasing ceramide
generation through caspase-3 activation, induction of mitochondrial permeability transition, and …

Apoptosis and oxidative stress in neurodegenerative diseases

E Radi, P Formichi, C Battisti… - Journal of Alzheimer's …, 2014 - content.iospress.com
… Our group showed a high sensitivity to oxidative stress and an evident increase in apoptotic
cell death in PBLs from KRS patient with the c.G2629A mutation in ATP13A2, suggesting a …

Mitochondrial oxidative stress plays a key role in aging and apoptosis

J Sastre, FV Pallardó, J Viña - IUBMB life, 2000 - Wiley Online Library
… that mitochondrial oxidative stress is an early event in apoptosis (115). In fact, oxidation of
mito… membrane potential from apoptotic fi broblasts and an increase in the peroxide content of …

Regulation and measurement of oxidative stress in apoptosis

JF Curtin, M Donovan, TG Cotter - Journal of immunological methods, 2002 - Elsevier
oxidative stress and apoptosis. Finally, the various methods that can be employed in establishing
a role for both ROS and RNI in apoptosis … indicates increased levels of oxidative stress. …

Oxidative stress and apoptosis in neurodegeneration

AM Gorman, A McGowan, C O'Neill, T Cotter - Journal of the neurological …, 1996 - Elsevier
… of dopamine, which presumably acts by increasing the amount of dopamine released by
surviving neurons. There is evidence of oxidative stress in Parkinson’s disease (Olanow, 1992) …