… The Immp2l mutant mice have impaired processing of signal peptide of cytochrome c1 and
… ion, hyperpolarization of mitochondria, and increased oxidative stress in multiple organs. …

… oxidative stress and mitochondrial dysfunction. Parkin-null Drosophila 54 and mouse 55 strains
exhibit mitochondrial impairment and increased oxidative stress, … selective impairment in …

… that increased oxidative stress and … of mitochondria in the pathogenesis of neurodegenerative
diseases, however it is unclear whether mitochondrial impairment and oxidative stress are …

… oxidative species and mitochondria are playing important roles in NDDs. This review discusses
the effects of the oxidative stresses and mitochondrial … leading to impaired mitochondrial …

… on the role of mitochondrial defects on oxidative stress. Mitochondrial respiratory chain and
… here is whether OXPHOS defects are responsible for an increased oxidative stress in vivo. …

… Hence, the administration of mitochondrial protecting agents, energy … Oxidative stress and
mitochondrial impairment are two mechanistically interrelated events (Fig. 1). Mitochondria …

… of mitochondrial ROS production in premature aging. To address the role of mitochondrial
impairment and ROS production for aging in human muscles, we have analyzed mitochondrial …

… others revealed impaired • NO signaling, vascular inflammation and oxidative stress as
key players in the pathogenesis of aging dependent endothelial dysfunction (for review see [28]). …

… It is still largely debated whether oxidative stress and mitochondrial impairment are involved
in the onset and progression of all these neurodegenerative disorders or are merely a …

… Taken together, these results indicate that mitochondrial impairment caused by mtDNA
mutations and mutations of nuclear encoded mitochondrial proteins might be involved in PD …