In vitro–in silico comparison of pulsed oxygen delivery from portable oxygen concentrators versus continuous flow oxygen delivery

JZ Chen, IM Katz, M Pichelin, K Zhu, G Caillibotte… - Respiratory …, 2019 - rc.rcjournal.com
… between pulse flow and continuous flow oxygen, and among pulse flow … delivery than
continuous flow oxygen, continuous flow oxygen delivered a greater absolute volume of oxygen

Oxygen delivery by blood determines the maximal Vo2 and work rate during whole body exercise in humans: in silico studies

P Liguzinski, B Korzeniewski - American Journal of …, 2007 - journals.physiology.org
… The main aim of the present in silico study was to test in a quantitative way whether an …
oxygen) kept constant, will cause oxygen supply by blood to become limiting for maximal oxygen

Relating pulmonary oxygen uptake to muscle oxygen consumption at exercise onset: in vivo and in silico studies

N Lai, RK Dash, MM Nasca, GM Saidel… - European journal of …, 2006 - Springer
… To relate the total oxygen concentration C T x to free oxygen concentration C F x (x=art,
cap, tis), we consider oxygen in free and (hemoglobin) bound forms in arterial and capillary …

[HTML][HTML] In silico analysis of hypoxia activated prodrugs in combination with anti angiogenic therapy through nanocell delivery

C Meaney, S Rhebergen… - PLoS computational …, 2020 - journals.plos.org
… Specifically, it is crucial that our model include the effects of decreased oxygen delivery
due to overvascularization as well as increased consumption due to cell proximity. However, …

In silico modeling of oxygen‐enhanced MRI of specific ventilation

W Kang, MH Tawhai, AR Clark, RC Sá… - Physiological …, 2018 - Wiley Online Library
… Specific ventilation imaging (SVI) proposes that using oxygen-enhanced 1H MRI to capture
… In this study, we utilized two patient-based in silico models of ventilation, perfusion, and gas …

Comparison of pulsed versus continuous oxygen delivery using realistic adult nasal airway replicas

JZ Chen, IM Katz, M Pichelin, K Zhu… - … journal of chronic …, 2017 - Taylor & Francis
… conserve oxygen. The primary aims of this study were to develop a predictive in vitro model
for inhaled oxygen delivery … POC with steady flow (SF) from a compressed oxygen cylinder. …

In silico models of aerosol delivery to the respiratory tract—development and applications

PW Longest, LT Holbrook - Advanced drug delivery reviews, 2012 - Elsevier
… benefits of in silico models. … delivery, specification of conditions for optimal nasal delivery,
analysis of a new condensational delivery approach, and an evaluation of targeted delivery

In silico modelling of physiologic systems

RB Colquitt, DA Colquhoun, RH Thiele - Best practice & research Clinical …, 2011 - Elsevier
… they call the ‘oxygen excess factor’, SaO 2 /Sa-vO 2, as an index of oxygen delivery to oxygen
… 2 /Sa-vO 2 and systemic oxygen delivery. As demonstrated by this work by Barnea et al., in …

An in silico analysis of oxygen uptake of a mild COPD patient during rest and exercise using a portable oxygen concentrator

I Katz, M Pichelin, S Montesantos… - … Journal of Chronic …, 2016 - Taylor & Francis
delivery method to continuous-flow delivery cannot be achieved. Furthermore, the timing of
the oxygen … that the shape of the oxygen flow curve, as the dose is delivered, may also impact …

'In Vitro', 'In Vivo' and 'In Silico' Investigation of the Anticancer Effectiveness of Oxygen-Loaded Chitosan-Shelled Nanodroplets as Potential Drug Vector

A Khadjavi, I Stura, M Prato, VG Minero… - Pharmaceutical …, 2018 - Springer
… -loaded nanobubbles and decafluoropentane-based oxygen-loaded nanodroplets … oxygen
delivery either in vitro or in vivo (7,8,9,10). Chitosan-shelled/decafluoropentane-cored oxygen