… , is closely correlated with oxygen homeostasis regulation. … cardiovascular diseases, intended
to improve therapeutic approaches for clinical diagnoses. Better knowledge of the oxygen …

… , 265 aging,162, 272, 273 and chronic diseases such as diabetes273-275 and are co-opted …
for inhibition or activation in cancer and cardiovascular disease, respectively, are underway.…

… Cancer and ischemic cardiovascular disease are also characterized by disordered
oxygen homeostasis and, as such, are likely to respond to HIF-targeted therapies.28, 84 …

… , ROS can exhibit the deleterious effect on redox homeostasis leading to intracellular
components damage as seen in neurodegenerative diseases, CVDs, and pulmonary disorders [5]. …

… species that are known to be active in the cardiovascular system. This … oxygen species
sources in cardiovascular disease and both animal and human data defining how reactive oxygen …

… Oxidative stress originates in cells and tissues when reactive oxygen species (ROS) …
within mitochondrial matrix where they control energy metabolism and ROS homeostasis. …

… led to a reduction in basal and maximal oxygen consumption rate and total cellular ATP
levels, as well as an increase in mitochondrial reactive oxygen species (ROS) levels, finally …

… the prevalent disease conditions (cardiovascular diseases, neurodegeneration, diabetes,
etc.) is oxidative stress a confounder, which might change the patient’s susceptibility to oxygen-…

… Accumulated evidence from clinical and experimental animal studies supports a decisive
role for redox signaling in cardiovascular homeostasis and disease. ROS play a crucial role in …

… ROS-induced secreted CyPA contributed to several cardiovascular diseases in vivo. By …
CyPA mediates a variety of cardiovascular diseases including vascular stenosis, atherosclerosis, …