[HTML][HTML] Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rate

FL Sheeran, S Pepe - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2006 - Elsevier
… of reactive oxygen species (ROS) has been shown to increase in the failing heart, and due
… lipids may be targets of oxidative damage in the failing heart. In this brief review, we describe …

Reactive oxygen species, mitochondria, and NAD (P) H oxidases in the development and progression of heart failure

D Sorescu, KK Griendling - Congestive Heart Failure, 2002 - Wiley Online Library
… of reactive oxygen species (ROS) in heart failure. Because myocardial ischemia is one of
the most frequent causes of heart failure, the initial studies were focused on the role of oxygen

[HTML][HTML] Oxygen, oxidative stress, hypoxia, and heart failure

FJ Giordano - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
… more oxygen per gram tissue than a smaller one. Therefore, irrespective of the etiology, a
failing dilated heart requires more oxygen per gram tissue than a nonfailing smaller heart. The …

Mitochondrial Oxidative Stress in Heart Failure: “Oxygen Wastage” Revisited

DB Sawyer, WS Colucci - Circulation research, 2000 - Am Heart Assoc
… in the failingheart failure. In the present study, Ide et al 1 extend their earlier observations
by showing that the production of reactive oxygen species (ROS) is increased in the failing

Parsing the role of NADPH oxidase enzymes and reactive oxygen species in heart failure

AM Shah - Circulation, 2015 - Am Heart Assoc
oxygen speciesheart failure, numerous clinical trials of antioxidant therapies were undertaken
but were unsuccessful. Nevertheless, experimental data linking oxidative stress and heart

Targeting mitochondrial calcium handling and reactive oxygen species in heart failure

A Dietl, C Maack - Current heart failure reports, 2017 - Springer
… Since the first description of oxidative stress in heart failure, reactive oxygen species (ROS) …
and current strategies in targeting mitochondrial calcium handling and ROS in heart failure. …

Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium

F Sam, DL Kerstetter, DR Pimental, S Mulukutla… - … of cardiac failure, 2005 - Elsevier
failing, explanted human hearts in patients with nonischemic dilated cardiomyopathy at the
time of heart transplant to examine whether reactive oxygen species (… human heart failure. …

Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species

EM Redout, MJ Wagner, MJ Zuidwijk… - Cardiovascular …, 2007 - academic.oup.com
… Objective Reactive oxygen species (ROS) have been implicated in the progression of
ventricular hypertrophy to congestive heart failure. However, the source of increased oxidative …

Reactive oxygen species induced pathways in heart failure pathogenesis and potential therapeutic strategies

A Mongirdienė, L Skrodenis, L Varoneckaitė… - Biomedicines, 2022 - mdpi.com
… , chronic heart failure (CHF) is classified into heart failure (HF… increased formation of reactive
oxygen species (ROS) and … ) dysfunction and hypertrophy in the failing heart [7]. Therefore, …

Elevated Cytosolic Na+ Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes

M Kohlhaas, T Liu, A Knopp, T Zeller, MF Ong… - Circulation, 2010 - Am Heart Assoc
… reactive oxygen species production in the failing heart. … In chronic heart failure, oxidative
stress is causally linked to … sources of reactive oxygen species (ROS) in the heart. ROS impair …