Oxytocin and behavior: Lessons from knockout mice

HK Caldwell, EA Aulino, AR Freeman… - Developmental …, 2017 - Wiley Online Library
… that various mouse knockouts of the Oxt system have made to our understanding of Oxt's
modulation of behavior. We specifically focus on how the use of these mice has shed light on …

The social deficits of the oxytocin knockout mouse

JT Winslow, TR Insel - Neuropeptides, 2002 - Elsevier
… Here we review the results of studies in oxytocin knockout OTKO) mice. Mice with a null …
For this reason, we examined the behavior of OTKO mice in maternal behavior, infant ultrasonic …

Maternal behavior deficits in nulliparous oxytocin knockout mice

CA Pedersen, SV Vadlamudi… - … , Brain and Behavior, 2006 - Wiley Online Library
oxytocin knockout (OTKO) mice found no maternal behavior … In this study, we compared
maternal behavior exhibited by … Behavior was measured for 3.5 h after which pups and test …

Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors

RLH Pobbe, BL Pearson, EB Defensor, VJ Bolivar… - … and behavior, 2012 - Elsevier
… to characterize the behavioral phenotype of Oxtr KO mice, as compared to their WT counterparts,
more specifically in regards to the expression of autism-related behaviors. Three tests (…

Social approach behaviors in oxytocin knockout mice: comparison of two independent lines tested in different laboratory environments

JN Crawley, T Chen, A Puri, R Washburn, TL Sullivan… - Neuropeptides, 2007 - Elsevier
… If the social deficits in oxytocin knockout mice are more global to social approach behaviors
in general, then we hypothesized that oxytocin null mutant mice would show reduced levels …

Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice

ME Rich, EJ DeCárdenas, HJ Lee, HK Caldwell - PloS one, 2014 - journals.plos.org
behavior, mood and anxiety, we designed a study using Oxtr −/− mice that separated nursing
behavior … nipples) of Oxtr +/+ mice and sham-thelectomizing Oxtr −/− mice, and pairing both …

A conditional knockout mouse line of the oxytocin receptor

HJ Lee, HK Caldwell, AH Macbeth, SG Tolu… - …, 2008 - academic.oup.com
… Females of both KO types deliver pups, but only the Oxtr FB/FB mice are … Our results confirm
the importance of oxytocin in social … , behavioral, and developmental roles of the receptor. …

Female oxytocin gene‐knockout mice, in a semi‐natural environment, display exaggerated aggressive behavior

AK Ragnauth, N Devidze, V Moy… - … Brain and Behavior, 2005 - Wiley Online Library
behavioral differences between genotypes and all mice exhibited normal estrous cycling
patterns. Heterozygous mice … , because obtaining data from 18 mice (six of each genotype) …

Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice

H Higashida, O Lopatina, T Yoshihara… - Journal of …, 2010 - Wiley Online Library
… affecting oxytocin activity in the context of social behavior. (a) … for oxytocin secretion in
hypothalamic oxytocin neurones (27). … behaviour and oxytocin levels in CD38 knockout mice, and …

The impact of oxytocin gene knockout on sexual behavior and gene expression related to neuroendocrine systems in the brain of female mice

JM Zimmermann-Peruzatto, VM Lazzari… - Cellular and molecular …, 2017 - Springer
… in the modulation of sexual behavior in females. This study aimed to analyze the impact
of OT gene knockout (OTKO) on sexual behavior and the gene expression of oxytocin (OTR), …