The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

C Maud, J Ryan, JE McIntosh, CA Olsson - BMC psychiatry, 2018 - Springer
… This review brings together early findings in a rapidly developing field of research,
examining relationships between DNA methylation (DNAm) of the Oxytocin Receptor Gene (OXTR) …

DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli

A Jack, JJ Connelly, JP Morris - Frontiers in human neuroscience, 2012 - frontiersin.org
… the level of DNA methylation of OXTR would predict … OXTR methylation and brain activity
evoked by the perception of animacy. Our results suggest that consideration of DNA methylation

DNA methylation of the human oxytocin receptor gene promoter regulates tissue-specific gene suppression

C Kusui, T Kimura, K Ogita, H Nakamura… - Biochemical and …, 2001 - Elsevier
… In the human oxytocin receptor (OTR) gene, there is a CpG island from 140 bp upstream to
… whether the methylation state of this region affects the transcription of the OTR gene. HepG2 …

Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits–A systematic review

M Moerkerke, ML Bonte, N Daniels, V Chubar… - Research in Autism …, 2021 - Elsevier
oxytocin receptor gene (OXTR) DNA methylation (DNAm) … OXTR DNAm in relation to ASD,
social perception/cognition and social anxiety were included. We found that hypermethylation

DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety …

YC Chagnon, O Potvin, C Hudon, M Préville - Frontiers in genetics, 2015 - frontiersin.org
OXTR, a greater DNA methylation was observed in subjects with anxiety/depression, but only
for those carrying the AA genotype of the OXTRoxytocin receptor (OXTR) is another gene

Reduced DNA methylation of the oxytocin receptor gene is associated with obsessive-compulsive disorder

CI Park, HW Kim, S Jeon, JI Kang, SJ Kim - Clinical epigenetics, 2020 - Springer
… between OXTR DNA methylationDNA methylation level of OXTR between patients with
OCD and healthy controls. To exclude the potential effects of medication on DNA methylation in …

Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

JP Gouin, QQ Zhou, L Booij, M Boivin, SM Côté… - Scientific Reports, 2017 - nature.com
oxytocin receptor gene (OXTR) methylation among young adults. Drawing from a 21-year
longitudinal cohort, we compared adulthood OXTR methylation … between OXTR methylation

The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity

S Müller, M Sicorello, D Moser, L Frach… - Translational …, 2023 - nature.com
oxytocin receptor gene (OXTR) is of interest when investigating the effects of early adversity
on DNA methylation. … clusters of CpG sites within the OXTR CpG island in 113 mother-infant …

Oxytocin receptor DNA methylation in postpartum depression

M Kimmel, M Clive, F Gispen, J Guintivano… - …, 2016 - Elsevier
gene expression modulating effects of estradiol on the OXTR, we sought to test the hypothesis
that OXTR DNA methylationOXTR DNA methylation. We sought to test the hypothesis that …

Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression

JS Danoff, KL Wroblewski, AJ Graves, GC Quinn… - Clinical …, 2021 - Springer
… In order to determine if this model is instructive for studying humans, we compared OXTR
DNA methylation to gene expression from human samples collected from Brodmann Area 41/…